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The GutāBrain Superhighway in Huntingtonās Disease: Clues From the Microbes Inside Us
The gut and brain are connected by a busy two-way superhighway. In Huntingtonās disease, traffic on this road may be jammed, detoured, or carrying harmful cargo, linking gut microbes, inflammation, and brain health in surprising ways.
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Carried from Childhood: Childhood Experiences and Adult Mental Health in Families with Huntingtonās Disease
Some childhood experiences stay with us, quietly shaping how we feel as adults. For those raised in families with Huntingtonās disease, this new study helps make sense of those feelings, and reminds us that healing is possible.
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Body in Decline: Muscle Loss as an Early Symptom of Huntingtonās Disease
Huntingtonās disease doesnāt just damage the brain, it also breaks down muscles and fat, and disrupts nutrition early on. New work suggests thereās a hidden physical decline in early HD, so monitoring body changes could help with better care.
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Appetite for Answers: Does Eating on a Schedule Help with Huntingtonās Disease?
A new review explores whether time-restricted eating (TRE) could help manage Huntingtonās disease (HD) by boosting brain health in animal models. While the science is exciting, there are real risks for people with HD.
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July 2025: This Month in Huntingtonās Disease Research
Julyās HD research roundup: Brain scans, gene editing, glial cells, and even smartphones reveal new ways to track and treat Huntingtonās. From sleep to cell power, science is zooming in and bringing hope for earlier, smarter interventions.
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When the Brainās Clock Breaks: Sleep Disruption and Circadian Chaos in Huntingtonās Disease
A 12-year study reveals how disrupted sleep may predict Huntingtonās disease onset, could link to changes in thinking and thought processing, and contribute to nerve damage. Sleep isnāt just rest, itās a vital brain process for brain health.
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Pridopidine Hits a Roadblock: EMA Says No to Approval for Huntingtonās Disease Treatment
The EMA has rejected pridopidine for HD treatment in Europe. While disappointing, this outcome aligns with the trial data. Prilenia plans further studies, and despite setbacks, HD research in 2025 continues to bring momentum and hope.
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When the Brainās Orchestra Falls Out of Tune: A New Map of Huntingtonās Disease Progression
New research maps Huntingtonās disease progression like a symphony unraveling. The brain first overcommunicates, then loses sync, and finally falls silent, each stage driven by different biological mechanisms.
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Stopping the Genetic Snowball: How a simple genetic interruption slows Huntingtonās disease
The Huntington’s disease mutation worsens over time like a dangerous snowball. By harnessing the power of the gene editing tool CRISPR, scientists may have found a way to interrupt the HD mutation and stall disease onset.
By AJ Keefe -
Unsung Heroes: Could Glial Cells Treat Huntingtonās Disease?
Transplanting healthy human glial cells into HD mouse brains improved movement, memory, and survival. Even more strikingly, the glia coaxed diseased neurons to behave more like healthy ones, offering a potential new path for treating HD.