featured
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Picking MSH3ās Pocket: New Insights into CAG Repeat Expansion
8 min read
Scientists discovered a pocket on a protein called MSH3 that helps it grab DNA containing CAG repeats. By blocking this interaction, they slowed the growth of CAG repeats in cells, without removing the protein entirely.
By Dr Leora Fox -
What Pigs Revealed that Mice Missed in Huntingtonās Disease
9 min read
A change in one gene can disrupt thousands of others in HD. A study in pigs suggests an explanation: expanded huntingtin interferes with chemical marks on DNA. The same effect wasnāt seen in mice, showing that the animal model matters.
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Mending the fabric of your genes
6 min read
Cells constantly mend tears and rips in the fabric of your DNA, like a cherished pair of jeans. Sometimes this mending can add C-A-Gs by mistake. A group of scientists examined whether other kinds of rips in the genetic fabric may be occurring in HD.
By Dr Chris Kay -
Could rewiring the brain’s “brakes” improve movement in Huntington’s disease?
6 min read
Scientists discovered that a specific type of brain cell becomes unusually quiet in Huntington’s disease. By restoring the activity of these cells in mice, they were able to rebalance brain circuits and improve movement.
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Your Voice Matters: Using Speech to Monitor Huntington’s Disease
9 min read
HD researchers developed an AI-powered tool that analyzes a short counting task. Its speech measures reflected clinical scores and HD-related changes over time, suggesting it could be used as a remote monitoring tool in future.
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Canāt Get You Out of My Head: The Huntingtonās Disease Symptom Thatās More Than Just Repetition
5 min read
Getting āstuckā on a thought, action, or conversation can be a symptom of HDānot stubbornness. New research suggests perseveration may begin earlier than previously thought and highlights the value of caregiver perspectives.
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AMT-130 at Four Years: Hopeful Signs, Complex Controls
12 min read
uniQure reports that after 4 years, people given high-dose AMT-130 continue to show signs of slower HD progression, providing hope for their recent regulatory submission. But the new analyses are nuanced. We unpack the hopeful, but complex results.
By Dr Leora Fox -
September 2026: This month in Huntingtonās disease research
5 min read
September brought progress across the HD research landscape. From brain waves and visual thinking to DNA repeats, nutrition, inclusive care, new technologies, and encouraging SKY-0515 data, we round up a busy month in Huntingtonās disease research.Ā
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Studying Stutters: What 900,000 genomes teach us about growing DNA repeats
7 min read
The CAG repeat that causes HD has a tendency to grow with age. New research on over 900,000 people uncovers parallel patterns and finds CAG growth can happen in many other parts of the genome.
By AJ Keefe -
Highlighting Mental Health Disparities in Indigenous Communities Affected by Huntington’s Disease
11 min read
Unique research highlights an overlooked mental health disparity among Indigenous North American people with HD – and the need for care grounded in trust, community partnership, and cultural understanding.