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July 2025: This Month in Huntingtonâs Disease Research
Julyâs HD research roundup: Brain scans, gene editing, glial cells, and even smartphones reveal new ways to track and treat Huntingtonâs. From sleep to cell power, science is zooming in and bringing hope for earlier, smarter interventions.
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When the Brainâs Clock Breaks: Sleep Disruption and Circadian Chaos in Huntingtonâs Disease
A 12-year study reveals how disrupted sleep may predict Huntingtonâs disease onset, could link to changes in thinking and thought processing, and contribute to nerve damage. Sleep isnât just rest, itâs a vital brain process for brain health.
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Pridopidine Hits a Roadblock: EMA Says No to Approval for Huntingtonâs Disease Treatment
The EMA has rejected pridopidine for HD treatment in Europe. While disappointing, this outcome aligns with the trial data. Prilenia plans further studies, and despite setbacks, HD research in 2025 continues to bring momentum and hope.
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When the Brainâs Orchestra Falls Out of Tune: A New Map of Huntingtonâs Disease Progression
New research maps Huntingtonâs disease progression like a symphony unraveling. The brain first overcommunicates, then loses sync, and finally falls silent, each stage driven by different biological mechanisms.
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Stopping the Genetic Snowball: How a simple genetic interruption slows Huntingtonâs disease
The Huntington’s disease mutation worsens over time like a dangerous snowball. By harnessing the power of the gene editing tool CRISPR, scientists may have found a way to interrupt the HD mutation and stall disease onset.
By AJ Keefe -
Unsung Heroes: Could Glial Cells Treat Huntingtonâs Disease?
Transplanting healthy human glial cells into HD mouse brains improved movement, memory, and survival. Even more strikingly, the glia coaxed diseased neurons to behave more like healthy ones, offering a potential new path for treating HD.
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Energy off balance: How Huntingtonâs disease influences the cellâs powerhouseÂ
Scientists used 3D mini-brains grown from stem cells to study Huntingtonâs disease. They found early developmental changes linked to mitochondrial stress, suggesting that energy imbalance may play a role in HD, even before neurons fully form.
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Peeking at huntingtin and learning from a PET study
Scientists tested a new tool to measure harmful HTT protein in HD. It wasnât perfect, but offered key insights to guide better tools already in the works. A big step toward tracking HD non-invasively, from inside the brain!
By Dr Leora Fox -
June 2025: This Month in Huntingtonâs Disease Research
June was filled with exciting research! Ranging from clinical trial updates to irritability, we’ve rounded up the most exciting Huntington’s disease research from this month.
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Trouble on the Block: When the Neighborhood Loses Its Best Firefighter
In HD, a key brain protector, PKD1, is missing. Without this âmolecular firefighter,â neurons are vulnerable. Knowing why it disappears may help us uncover how the brainâs defense break down, and how to reinforce it.