drug-development
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Could a 'brain shuttle' get Huntington's disease drugs to where they're needed?
Roche's 'brain shuttle' sneaks drugs past the blood-brain barrier. Could it work for HD gene silencing drugs?
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Is a new Huntington’s Disease drug study on the right Trk?
A recent HD animal study reveals that a small molecule drug could be an effective “Trk” to target for HD therapeutics
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New study sheds light on regional degeneration in HD
Why do certain brain cells die in HD? New research suggests is may be due to the efficiency of cellular recycling
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What the 'big neurodegeneration breakthrough' means for Huntington's disease
Are recent findings in mice injected with 'prions' as important for Huntington's disease as widely reported?
By Eric Minikel -
Targeting oxidative stress in Huntington's Disease
Damage to cells caused by oxidative stress is part of HD – could a new targeted drug help reduce this problem?
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Shooting the messenger with single-stranded RNA gene silencing
New ‘single-stranded RNA’ gene silencing drugs could be safer & more effective to treat Huntington’s disease
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Lithium with a twist gets second chance for HD
Lithium gets a second chance in HD – with a new chemical delivery method, tested in Huntington’s disease mice
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Phosphodiesterase inhibitors: new HD drugs entering trials soon
CHDI and Pfizer announce exciting animal work and plans for a human trial with a drug targeting 'phosphodiesterases'.
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'Floating' gene-silencing drugs into the brain with exosomes
Exosomes – tiny bubbles made by cells – could be used to get gene silencing drugs from the bloodstream into the brain