drug-development
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Targeting oxidative stress in Huntington's Disease
Damage to cells caused by oxidative stress is part of HD – could a new targeted drug help reduce this problem?
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Shooting the messenger with single-stranded RNA gene silencing
New āsingle-stranded RNAā gene silencing drugs could be safer & more effective to treat Huntingtonās disease
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Lithium with a twist gets second chance for HD
Lithium gets a second chance in HD – with a new chemical delivery method, tested in Huntingtonās disease mice
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Phosphodiesterase inhibitors: new HD drugs entering trials soon
CHDI and Pfizer announce exciting animal work and plans for a human trial with a drug targeting 'phosphodiesterases'.
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'Floating' gene-silencing drugs into the brain with exosomes
Exosomes ā tiny bubbles made by cells ā could be used to get gene silencing drugs from the bloodstream into the brain