cognition
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Stars in the Sky: Psychosis in Huntington’s Disease
New research shines a light on an often-overlooked side of Huntington’s disease—psychosis. Understanding the impact of psychosis on daily life and progression of other HD symptoms could be key to providing better care and support.
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Do Antidepressants Affect Cognitive Decline? There's More To The Story For Huntington's Disease
Recent research suggests a connection between antidepressant use and increased cognitive decline in people with dementia. However these finding shouldn't be blindly applied to Huntington's disease.
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Brain Gym: Staying Mentally Active May Slow Huntington’s Disease
New research suggests that cognitive engagement – keeping your brain busy with activities like reading, puzzles, or learning new skills – could help protect the brain, possibly slowing progression of symptoms of Huntington’s disease.
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The dust has settled: Sage’s dalzanemdor won’t advance for cognitive impairment
Changes in thinking, learning, and memory are some of the most distressing and impactful in Huntington’s disease. Sage Therapeutics was advancing their drug dalzanemdor to treat these symptoms, but unfortunately this program will be halted.
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14 changes for a healthier brain
In 2019, there were ~57 million people living with dementia. By 2050, that number is expected to climb to 153 million. Changes in the 14 factors highlighted here can improve brain health and be applied to Huntington’s disease.
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SURVEYOR opens the door for drugs that treat cognition
Sage Therapeutics announced results from SURVEYOR, a trial that looked at cognitive changes in people with HD, and tested short-term safety of dalzanemdor. The study was small but met key goals, and additional trials are in progress.
By Dr Leora Fox -
HD Young Adult Study defines the sweet spot: symptom-free with measurable changes
We know that HD-related changes can occur many years before symptom onset, but how early do those changes begin? A team of researchers set out to determine that with a new comprehensive study in pre-manifest HD young adults.
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Thinking clearly about the earliest symptoms of HD and which brain regions control them
HD reaches more brain structures than we thought: new research broadens our understanding of the earliest signs of HD
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Through a Broader Lens: Looking at Non-Motor Symptoms in HD
Sleep deficits precede motor problems in HD
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A multiple sclerosis drug that works for Huntington's disease: the real deal or too good to be true?
Fingolimod, a drug used in multiple sclerosis, prevents memory problems in HD mice. Would it work in patients?