animal-model
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HDBuzz Prize runner-up 2012: Fruit flies, faulty connections and Huntington's disease
Recent study in fruit flies identifies a new connection between synapses and HD
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New experiments clarify the role of SIRT1 in HD – or do they?
Work from multiple labs suggests activating a protein called SIRT1 might help HD, but the picture is still confusing
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Bone marrow transplantation in Huntington's Disease
Bone marrow transplant protects HD mice from some symptoms, suggesting the immune system may be an important target
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HDAC inhibitor drug protects memory in HD mice
CBP, a gene-switching protein, protects memory in HD mice; 'histone deacetylase inhibitor' drug mimics its effects
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Melatonin treatment success in HD mice
Melatonin delays disease onset and extends survival in Huntington's disease mice – could it do the same for patients?
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Protein-folding drug helps HD mice… for a while
A drug that activates an ancient cellular defense mechanism slows down HD in mice – but why didn’t the benefit last?
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Not all in your head: digestive problems in HD
Huntington's disease mice absorb less nutrition from food – which might help explain why human patients lose weight.
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Chubby mice reveal the importance of the hypothalamus in Huntington's disease
Huntington's disease mice are fat but HD patients lose weight – is a brain area called the hypothalamus to blame?
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What do sheep brains have to do with HD?
How smart are sheep, and why do HD researchers care?
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Anti-nausea drug helps cells with the HD mutation stay healthy in a surprising way
Anti-nausea drug meclizine protects cells with the HD mutation from death by reducing cellular energy production