animal-model
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Could molecular handcuffs lower the protein that causes Huntington's disease?
6 min read
Researchers got surprisingly lucky when looking for drug molecules to pull mutant huntingtin protein into a cellular garbage disposal machine
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Exciting new Huntingtin lowering tool described
8 min read
Exciting new Huntingtin Lowering work from @SangamoTx and @CHDIfoundation using "Zinc Fingers" to shut down expression of the mutant Huntingtin gene. More details on this exciting new technique here.
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Huntington's disease therapeutics conference 2019 – Day 2
5 min read
New tools to bridge the gap between the lab and patients in our update from day 2 of the 2019 HD Therapeutics conference
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Advances on many fronts in the battle against the protein that causes Huntington's disease
11 min read
This fall sees exciting announcements from a number of companies focused on novel Huntingtin Lowering technologies, including Wave, PTC and Voyager
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First Dolly, now Piglet; a new Huntington’s disease pig knock-in model confirmed
7 min read
For the first time in HD research, an animal model has been created in pigs using 2 cutting edge DNA editing t
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New roles for huntingtin: removing a healthy protein to understand its function
7 min read
Completely removing normal huntingtin in adults may disrupt healthy brain function, a recent study suggests.
By Dr Leora Fox -
Has a "wonder drug" for dementia been discovered? (Spoiler alert: no.)
8 min read
Media reports of a wonder drug for neurodegenerative diseases like Huntington's disease are overhyped
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Enemy at the gates – huntingtin disrupts nuclear transport
7 min read
Two recent studies show how a cellular border control system goes wrong in HD, opening new avenues for HD research.
By Tom Peskett -
Sheep leading the flock: metabolism and biomarkers in HD
8 min read
Sheep can help us to identify HD biomarkers and recognize metabolic changes that occur before symptoms develop.
By Dr Leora Fox -
Important advances in next generation genome editing tools for Huntington's Disease
13 min read
Work with genome editing techniques (zinc fingers and CRISPR) brings these tools closer to use in HD clinical trials