aggregates
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Hot techniques in HD research
11 min read
Five HD scientists discuss the cutting-edge techniques driving their work. These technical innovations will provide biological insights and move us closer to treatments.
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Taking A Short Cut: New Routes to Huntingtin-Lowering Therapies
6 min read
New research points to HTT1a, a toxic shortened form of huntingtin, as a key driver of disease and a promising therapeutic target in HD.
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Are we finally getting that PET we’ve always wanted?
7 min read
For the past 20 years, PET tracers have been a game-changer for Alzheimer’s disease, making it possible to see amyloid plaques in the brain without invasive procedures. So what about Huntington’s?
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Precision Pruning with PROTACs: Selective Targeting of Toxic Huntingtin
6 min read
PROTACs act like a precision pruning tool, trimming away toxic huntingtin protein while leaving the healthy form intact. In cells and HD mice, this targeted clean-up improved health and slowed disease features.
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Fixing the Recipe: Lowering a Slice of Huntingtin
8 min read
In a recent paper, scientists targeted a small, harmful piece of the huntingtin message (HTT1a) in HD mice. This reduced toxic protein clumps and delayed genetic changes, more than targeting full length HTT.
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Tagging the Trash: Turnover of Toxic Huntingtin
5 min read
A recent study suggests that strengthening the brain’s own clean-up system could slow Huntington’s disease.
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Blocking a toxic fragment: new mouse study highlights the importance of HTT1a in Huntington’s disease
9 min read
New research in a HD mouse model points to a key culprit: a small fragment called HTT1a. Lowering HTT1a levels successfully delayed disease signs in mice that model HD, perhaps shaping the next generation of HTT-lowering therapies.
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Worms to the Rescue: Separating the Good, the Bad, and the Clumpy Huntingtin
6 min read
A team of researchers developed a simple platform to test how toxic different types of HTT protein clumps are using a laboratory worm model. They showed that certain types of clumps are harmful to the worms, while others are not.
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Folding A Shirt With 12-Foot Arms: Understanding Protein Folding in Huntington’s Disease
6 min read
In a recent Nature Communications publication, a team of researchers investigated a new way to improve the protein folding process in HD and stop the formation of toxic clumps.
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A Tiny Genetic Tweak Could Delay Symptoms and Activate Cellular Cleanup for Huntington’s Disease
6 min read
Scientists discover a rare genetic quirk that may extend the age of onset in people with Huntington’s disease by boosting cellular cleanup.
By AJ Keefe