aggregates
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Blocking a toxic fragment: new mouse study highlights the importance of HTT1a in Huntingtonās disease
ā±ļø 9 min read |New research in a HD mouse model points to a key culprit: a small fragment called HTT1a. Lowering HTT1a levels successfully delayed disease signs in mice that model HD, perhaps shaping the next generation of HTT-lowering therapies.
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Worms to the Rescue: Separating the Good, the Bad, and the Clumpy Huntingtin
ā±ļø 7 min read | A team of researchers developed a simple platform to test how toxic different types of HTT protein clumps are using a laboratory worm model. They showed that certain types of clumps are harmful to the worms, while others are not.
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Folding A Shirt With 12-Foot Arms: Understanding Protein Folding in Huntingtonās Disease
In a recent Nature Communications publication, a team of researchers investigated a new way to improve the protein folding process in HD and stop the formation of toxic clumps.
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A Tiny Genetic Tweak Could Delay Symptoms and Activate Cellular Cleanup for Huntingtonās Disease
Scientists discover a rare genetic quirk that may extend the age of onset in people with Huntingtonās disease by boosting cellular cleanup.
By AJ Keefe -
2025 HDBuzz Prize: On the Frontlines: Trusting the Hall Monitors of the Cell
Weāre proud to announce Chloe Langridge as a 2025 HDBuzz Prize winner! A protein called SGTA shows promise as a target in HD therapeutics. Researchers find that increasing levels of SGTA in the cell helps reduce signs of HD.
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Peeking at huntingtin and learning from a PET study
Scientists tested a new tool to measure harmful HTT protein in HD. It wasnāt perfect, but offered key insights to guide better tools already in the works. A big step toward tracking HD non-invasively, from inside the brain!
By Dr Leora Fox -
Assembly Line Breakdown: Protein Production Problems in Huntingtonās Disease
Huntingtonās disease slows the cellās protein factory, causing production line jams & toxicity. A faulty blueprint & missing factory assistant worsen errors. Targeting production slowdowns, not just misfolded products, may help fix the assembly line.
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Getting to the Root of Huntington's Disease: A Plant-Based Approach
Researchers used plants to study how to stop the Huntingtonās disease protein from forming toxic clumps
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Focusing in on fibrils; scientists give us a glimpse of huntingtin protein clumps
Scientists have used powerful microscopes to look at sticky fragments of the Huntingtonās disease protein, shedding light on these structures which are thought to drive the disease
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A first for CRISPR gene editing could have wider applications for human disease
A successful early trial of a drug for Familial Transthyretic Amyloidosis showed that CRISPR gene editing could be safely used in the human body. What does this mean for gene editing in HD?