Search HDBuzz
Going boldly: First person treated in Phase 1 clinical trial by Alnylam Pharmaceuticals
A new Phase 1 clinical trial for the huntingtin-lowering drug ALN-HTT02 was initiated this week with the first dose given. Read on to learn details about the trial and how it compares to other ongoing huntingtin-lowering trials in the clinic.
December 08, 2024
Interim update from Vico Therapeutics on their CAG-targeting drug, VO659
Vico Therapeutics have shared interim data about their drug, VO659, which targets the CAG expansion that causes several genetic diseases, including #Huntingtonsdisease and #spinocerebellarataxia
December 10, 2024
Moving into the Fast Lane: uniQure and the FDA Are on the Same Track for Accelerated Approval
In an update shared today, uniQure announced alignment with the US drug regulator on key criteria for accelerated approval of drugs for Huntington’s disease.
December 10, 2024
2024 HDBuzz Prize: A NEAT new dance partner for Huntingtin
We’re proud to announce AJ Keefe as our last HDBuzz Prize winner of 2024! Our cells are an intricate choreography between various molecular dancers. Knowing who moves well with whom, and how that changes with disease, could help advance drugs for HD.
December 23, 2024
2024: Year in Review
As we begin 2025, we look back on all of the Huntington’s disease research news and progress the field has made in the last 12 months.
January 02, 2025
Decoding apathy in Huntington’s disease: a new lens on motivation and decision-making
Apathy in Huntington’s disease isn’t just a lack of motivation—it’s a shift in how the brain weighs decisions. A new study sheds light on how targeted treatments could help restore motivation and improve quality of life.
January 06, 2025
Replacing What Is Lost: Regrowing Damaged Brain Cells for Huntington’s Disease
Cell replacement therapy is making massive strides for other diseases. But what about Huntington’s disease? Can we use technological advancements in this area to replace lost brain cells with the hope of repairing and reversing disease?
January 13, 2025
Beta-blockers associated with delayed onset and decreased progression of Huntington’s disease
A well-studied, widely used class of drugs for heart health may have benefits for Huntington’s disease. A new paper associated beta-blocker use with delayed onset and slower disease progression. Should you ask your doctor for a new prescription?
January 16, 2025
Spotting HD Early: The Clues Hidden in Young Brains
Researchers have detected early changes in brain scans and biomarkers in young people with the Huntington’s disease gene, 20 years before symptoms are predicted to appear. These findings could help develop medicines to treat HD earlier in life.
January 17, 2025
New Insights Into Why Huntington’s Disease Has Delayed Onset
A highly-anticipated scientific paper has landed! This new work challenges current theories in Huntington’s disease research, uncovering how runaway CAG repeats erode cell identity in certain types of brain cells, leading to their death.
January 20, 2025
You can also read About HDBuzz for information on HDBuzz or try your search on a search engine.