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FDA sets May 2027 decision date on AMT-130 gene therapy for HD
4 min read
Latest News
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October 2026: This Month in Huntington’s Disease Research
4 min read
From sticky thoughts and pigs that model HD to DNA repair and promising drug trial results, October brought fresh insights into HD. Here’s what you might have missed!
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Caffeine, cannabis and caution
8 min read
Does caffeine accelerate Huntington's disease? Does cannabis slow it down? HDBuzz looks behind the headlines
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Making babies: having a family, the HD way
17 min read
Making babies: HDBuzz's feature article – updated for 2024 – on fertility technologies that can help at-risk people to have HD-free children
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Re-routing the huntingtin protein inside cells
7 min read
Canadian team decodes the tags that re-route the huntingtin protein within cells, helping explain how it becomes toxi
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Not all in your head: digestive problems in HD
4 min read
Huntington's disease mice absorb less nutrition from food – which might help explain why human patients lose weight.
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Huntexil update: EMA asks for further trial
2 min read
European Medicines Agency (EMA) tells NeuroSearch a European license for Huntexil in HD requires another large trial
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KMO inhibitor drug improves lifespan of Huntington's disease mice
8 min read
Positive results from tests of a new 'KMO inhibiting' drug in Huntington's disease mice
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Meet the enemy: neutron ray reveals HD protein structure
5 min read
Scientists use beams of neutrons to study the structure of clumps of mutant huntingtin protein
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'Floating' gene-silencing drugs into the brain with exosomes
6 min read
Exosomes – tiny bubbles made by cells – could be used to get gene silencing drugs from the bloodstream into the brain
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Improving Huntington's disease clinical trial recruitment through patient and family education
5 min read
How can we improve recruitment into Huntington's disease clinical trials? Talking directly with families works!
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Chubby mice reveal the importance of the hypothalamus in Huntington's disease
6 min read
Huntington's disease mice are fat but HD patients lose weight – is a brain area called the hypothalamus to blame?
HDBuzz Trial Tracker
FDA accepts BLA for Priority Review, with a target decision date of 1 May 2027.
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Updates from the ongoing Phase 3 INVEST-HD trial of votoplam
Updates from the Phase 1b/2a REGEN4HD trial of neural stem cell therapy hNSC-01
Updates from the ongoing Phase 2/3 FALCON-HD trial of SKY-0515
