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Could rewiring the brain’s “brakes” improve movement in Huntington’s disease?
6 min read
Latest News
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Huntington's disease therapeutics conference 2018 – day 1
7 min read
Our daily roundup of the science presented at the 2018 HD Therapeutics Conference in Palm Springs
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An early role for the Huntington's disease gene – but don't believe all the headlines
13 min read
A surprising new paper sheds light on the role of the HD gene early in development. Should we worry?
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New interest in an old target
5 min read
Promising results in mice provide renewed optimism for mGluR5 antagonists
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Ask the expert: Q&A on the huntingtin-lowering trial program
14 min read
In a Q&A coordinated by the UK HD Association, Dr Ed Wild answers questions on the recently-announced trial
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Success! ASO drug reduces levels of mutant protein in Huntington's disease patients
11 min read
Amazing news from Ionis and Roche! HTTRx drug successfully lowers harmful huntingtin protein in spinal fluid
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Switch off the genome editor when you’re done
7 min read
CRISPR genome editing just got an off-switch. We cut through the hype to explore the technology in HD
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A new way of thinking about trials to prevent Huntington's disease
6 min read
Can we test drugs to delay or prevent the onset of Huntington's disease? New research suggests it's possible
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New roles for huntingtin: removing a healthy protein to understand its function
7 min read
Completely removing normal huntingtin in adults may disrupt healthy brain function, a recent study suggests.
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Precision huntingtin-lowering drug trials target the mutant protein
10 min read
WAVE Life Sciences launches PRECISION clinical trial to suppress the mutant Huntington's disease protein
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A step forward for gene editing: CRISPR-Cas9 and HD
9 min read
Evolving CRISPR-Cas9 techniques can now be used to edit the HD gene in a living mouse brain.
HDBuzz Trial Tracker
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Updates from the ongoing Phase 3 INVEST-HD trial of votoplam
Updates from the Phase 1b/2a REGEN4HD trial of neural stem cell therapy hNSC-01
Updates from the ongoing Phase 2/3 FALCON-HD trial of SKY-0515
