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What Pigs Revealed that Mice Missed in Huntington’s Disease
9 min read
Latest News
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HD2026 Milton Wexler Biennial Symposium Day 1
27 min read
Day 1 of HD2026 is a wrap! From what human brains can teach us about HD, to HTT1a, somatic CAG expansion and the normal biology of HTT, today’s talks spanned the spectrum from fundamental biology to potential treatments.
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Prilenia shares HD trial data with CHDI to help future research
6 min read
Clinical trial data can drive discovery long after a study ends. Prilenia donated placebo-arm data from 2 HD clinical trials to CHDI, a valuable resource for researchers to better understand placebo effects, HD progression and future trial design.
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Looking back and moving forward: Questions and lessons 4 weeks out from Roche’s disappointing news
10 min read
Roche’s decision to stop development of 2 HTT-lowering programmes is disappointing, but the story doesn’t end there. Years of research answered some key questions, raised many new ones, and will inform the next generation of HD trials.
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July 2026: This Month in Huntington’s Disease Research
8 min read
July was a hard month for Huntington’s disease research, with Roche ending two HD programs. But the month also brought promising new tools, a new player in somatic expansion, and important work on eating and self-awareness in HD.
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Putting it in print: a clinical trial trying to rein in runaway pruning
9 min read
Four years after announcing positive results in their trial of ANX005 (tanruprubart) for HD, Annexon has formally published the results. It’s safe, hits its target, and may have helped some participants – so what’s the holdup?
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Joining the Starting Lineup: MutLβ’s Role in DNA Repeat Expansions
7 min read
Scientists have known that MutLβ is linked to repeat expansion but not exactly how. A study reveals that the MutLβ protein complex is a main player supporting and interacting with key DNA repair proteins to drive DNA repeat expansions.
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Catching a Giant Protein: Five New Ways to Grab Huntingtin
8 min read
Scientists screened over a trillion tiny ring-shaped protein fragments to find ones that can grab onto the huntingtin. They captured huntingtin straight out of cells and discovered it’s almost always paired with a partner called HAP40.
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Mirror, Mirror on the Wall: When Self-Awareness Shifts in Huntington’s Disease
6 min read
A new study suggests that reduced awareness of symptoms, known as anosognosia, may appear even in the earliest stages of HD. The findings highlight that understanding symptom progression requires more than one perspective.
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More Than Just Food: The Hidden Challenges of Eating with Huntington’s Disease
8 min read
People with Huntington’s disease commonly experience unintended weight loss. A recent article identified the challenges around HD’s impact on eating and weight maintenance, and explored how families and professionals navigate them.
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Roche ends two Huntington’s disease drug programmes after disappointing results
10 min read
Roche announced it is stopping development of two of its huntingtin-lowering ASO drugs, tominersen and RG6496. This marks a disappointing end to an important chapter in HD clinical research.
HDBuzz Trial Tracker
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Updates from the ongoing Phase 3 INVEST-HD trial of votoplam
Updates from the Phase 1b/2a REGEN4HD trial of neural stem cell therapy hNSC-01
Updates from the ongoing Phase 2/3 FALCON-HD trial of SKY-0515
