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Spark ignited: first HD patient dosed in new Roche gene therapy trial
Latest News
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The latest volume of HD genetics research reveals new gems but also mysteries
Each person with HD has genetic spelling changes that can impact HD symptoms. Scientists have released the latest in a series of genetic studies examining these spelling changes, shining a light on new paths to develop treatments for HD.
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What does COVID-19 mean for Huntington’s disease families and HD research?
COVID-19 update: what does it mean for HD families, how does it impact HD research, and how has it changed the way science works?
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New molecule can reverse the Huntington's disease mutation in lab models
A collaborative team of scientists from Canada and Japan have identified a small molecule which can change the CAG-repeat length in different lab models of Huntington's disease. #HuntingtonsDisease #DrugDiscovery
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Huntington’s disease therapeutics conference 2020 – Day 3
HDBuzz reports from the annual Huntington’s disease therapeutics conference in Palm Springs
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Huntington’s disease therapeutics conference 2020 – Day 2
HDBuzz reports from the annual Huntington’s disease therapeutics conference in Palm Springs
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Huntington’s disease therapeutics conference 2020 – Day 1
HDBuzz reports from the annual Huntington’s disease therapeutics conference in Palm Springs
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Screening the entire genome for new drug targets for HD
Scientists screen the ENTIRE genome to find new potential therapeutic targets for HD. This ambitious study provides a wealth of data for HD researchers
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The third dimension: using minibrains to understand brain development changes in HD
Researchers show that highly expanded CAGs in the HD gene can cause early developmental changes using 3D brain models called organoids. What’d they find?
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Unpacking Wave's PRECISION-HD2 huntingtin-lowering trial announcement
Wave Life Sciences announces that its antisense drug WVE-120102 has lowered mutant huntingtin protein in cerebrospinal fluid, but investors seem disappointed. Rather confusing – what do we know for sure?
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Could molecular handcuffs lower the protein that causes Huntington's disease?
Researchers got surprisingly lucky when looking for drug molecules to pull mutant huntingtin protein into a cellular garbage disposal machine
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Exciting new Huntingtin lowering tool described
Exciting new Huntingtin Lowering work from @SangamoTx and @CHDIfoundation using "Zinc Fingers" to shut down expression of the mutant Huntingtin gene. More details on this exciting new technique here.