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FDA sets May 2027 decision date on AMT-130 gene therapy for HD
4 min read
Latest News
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October 2026: This Month in Huntington’s Disease Research
4 min read
From sticky thoughts and pigs that model HD to DNA repair and promising drug trial results, October brought fresh insights into HD. Here’s what you might have missed!
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Body in Decline: Muscle Loss as an Early Symptom of Huntington’s Disease
7 min read
Huntington’s disease doesn’t just damage the brain, it also breaks down muscles and fat, and disrupts nutrition early on. New work suggests there’s a hidden physical decline in early HD, so monitoring body changes could help with better care.
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Appetite for Answers: Does Eating on a Schedule Help with Huntington’s Disease?
9 min read
A new review explores whether time-restricted eating (TRE) could help manage Huntington’s disease (HD) by boosting brain health in animal models. While the science is exciting, there are real risks for people with HD.
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July 2025: This Month in Huntington’s Disease Research
8 min read
July’s HD research roundup: Brain scans, gene editing, glial cells, and even smartphones reveal new ways to track and treat Huntington’s. From sleep to cell power, science is zooming in and bringing hope for earlier, smarter interventions.
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When the Brain’s Clock Breaks: Sleep Disruption and Circadian Chaos in Huntington’s Disease
6 min read
A 12-year study reveals how disrupted sleep may predict Huntington’s disease onset, could link to changes in thinking and thought processing, and contribute to nerve damage. Sleep isn’t just rest, it’s a vital brain process for brain health.
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Pridopidine Hits a Roadblock: EMA Says No to Approval for Huntington’s Disease Treatment
5 min read
The EMA has rejected pridopidine for HD treatment in Europe. While disappointing, this outcome aligns with the trial data. Prilenia plans further studies, and despite setbacks, HD research in 2025 continues to bring momentum and hope.
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When the Brain’s Orchestra Falls Out of Tune: A New Map of Huntington’s Disease Progression
7 min read
New research maps Huntington’s disease progression like a symphony unraveling. The brain first overcommunicates, then loses sync, and finally falls silent, each stage driven by different biological mechanisms.
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Stopping the Genetic Snowball: How a simple genetic interruption slows Huntington’s disease
8 min read
The Huntington’s disease mutation worsens over time like a dangerous snowball. By harnessing the power of the gene editing tool CRISPR, scientists may have found a way to interrupt the HD mutation and stall disease onset.
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Cracking the Case: How a Smartphone “Detective” is Helping Track Huntington’s Disease Progression
7 min read
Smartphones can help scientists calculate a new clinical measure of HD, called the HD Digital Motor Score. Easier data collection could means less clinic trips, fewer people needed for studies, and a better understanding of HD.
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Unsung Heroes: Could Glial Cells Treat Huntington’s Disease?
7 min read
Transplanting healthy human glial cells into HD mouse brains improved movement, memory, and survival. Even more strikingly, the glia coaxed diseased neurons to behave more like healthy ones, offering a potential new path for treating HD.
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Simon Says Stop: What a Children’s Game Can Teach Us About Early Huntington’s Disease
6 min read
Simon Says isn’t just a game, it’s a window into early HD! In this study, tiny thumb twitches reveal how attention slips before impulsivity kicks in. Understanding this could help catch HD sooner & improve support. Ready to play?
HDBuzz Trial Tracker
FDA accepts BLA for Priority Review, with a target decision date of 1 May 2027.
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Updates from the ongoing Phase 3 INVEST-HD trial of votoplam
Updates from the Phase 1b/2a REGEN4HD trial of neural stem cell therapy hNSC-01
Updates from the ongoing Phase 2/3 FALCON-HD trial of SKY-0515
