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When the Brain’s Clock Breaks: Sleep Disruption and Circadian Chaos in Huntington’s Disease
Latest News
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Artificial intelligence to save the day? How clever computers are helping us understand Huntington’s disease.
Scientists at IBM and the CHDI Foundation have used artificial intelligence to analyse datasets from Huntington’s disease observational trials to model progression of the disease. They hope their findings will help improve clinical trial design.
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A new roadmap to track Huntington’s disease progression
Researchers have updated the system that classifies Huntington’s disease progression. Tracking progression in 4 stages will make clinical trial screening and data interpretation easier and faster, and pave the way for pre-symptomatic trials.
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Revisiting vitamin therapy for HD
A small clinical trial of high-dose biotin and thiamine for treating HD is being planned in Spain. This trial is based on research that links HD to another neurodegenerative disease called biotin-thiamine responsive basal ganglia disease (BTBGD).
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A spoonful of branaplam helps the huntingtin go down
Branaplam was originally designed to treat spinal muscular atrophy, but a new paper outlines how it could hold promise for treating Huntington’s. This oral drug lowers huntingtin protein and will now be tested in a study called VIBRANT-HD.
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Huntington’s disease therapeutics conference 2022 – Day 3
Check out research updates from Day 3 of the 2022 HD Therapeutics Conference #HDTC2022
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Huntington’s disease therapeutics conference 2022 – Day 1
Check out research updates from Day 1 of the 2022 HD Therapeutics Conference #HDTC2022
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Huntington’s disease therapeutics conference 2022 – Day 2
Check out research updates from Day 2 of the 2022 HD Therapeutics Conference #HDTC2022
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Shining a spotlight on huntingtin: a tool to measure huntingtin-lowering in real time
A new imaging tool means that scientists can now directly measure the levels of the toxic huntingtin protein in animal models of Huntington’s disease, letting us see how well huntingtin lowering therapies are working in their brains
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BAC to basics: a more accurate mouse model for Huntington's disease
A genetically-tweaked Huntington's disease mouse model shows a tendency for the CAG repeat to grow, just like we see in humans with the mutation.
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Oral drug may change the story for huntingtin lowering
Researchers with PTC Therapeutics recently published exciting new findings – a promising new huntingtin lowering drug that can be taken as a pill. Will this change how we move forward with huntingtin lowering?