post-translational-modification
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What Pigs Revealed that Mice Missed in Huntington’s Disease
9 min read
A change in one gene can disrupt thousands of others in HD. A study in pigs suggests an explanation: expanded huntingtin interferes with chemical marks on DNA. The same effect wasn’t seen in mice, showing that the animal model matters.
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Does a 'rusty hinge' cause Huntington's disease?
8 min read
Canadian scientists have found that the mutant huntingtin protein is less flexible than normal.
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The 'N17' region of huntingtin protein: an address label in Huntington's disease?
7 min read
New research sheds light on where the huntingtin protein ends up inside our cells, and why
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Special 'brain fat' injection helps HD mice
5 min read
Directly injecting the brains of HD mice with a good type of fat called ganglioside GM1 provides dramatic benefit
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Re-routing the huntingtin protein inside cells
7 min read
Canadian team decodes the tags that re-route the huntingtin protein within cells, helping explain how it becomes toxi