observational
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Beta-blockers associated with delayed onset and decreased progression of Huntington’s disease
A well-studied, widely used class of drugs for heart health may have benefits for Huntington’s disease. A new paper associated beta-blocker use with delayed onset and slower disease progression. Should you ask your doctor for a new prescription?
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A new roadmap to track Huntington’s disease progression
Researchers have updated the system that classifies Huntington’s disease progression. Tracking progression in 4 stages will make clinical trial screening and data interpretation easier and faster, and pave the way for pre-symptomatic trials.
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When genes are unstable: targeting somatic instability in HD
CAG repeats expand in some parts of the body and brain as people with HD get older, a phenomenon known as somatic instability. Learn more about how researchers are exploring somatic instability and DNA repair to design therapies for HD.
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HD Young Adult Study defines the sweet spot: symptom-free with measurable changes
We know that HD-related changes can occur many years before symptom onset, but how early do those changes begin? A team of researchers set out to determine that with a new comprehensive study in pre-manifest HD young adults.
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HDBuzz Enrolls in Enroll-HD
As promised, HDBuzz's Jeff Carroll finally signed up for the Enroll-HD study. Learn more about this important global HD "observational study" here.
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A new way of thinking about trials to prevent Huntington's disease
Can we test drugs to delay or prevent the onset of Huntington's disease? New research suggests it's possible
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Planting trees together: The 2016 Huntington's Disease Society of America Convention
HDBuzz summarizes the science from an unusually large and energized @HDSA convention in Baltimore
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Through the eyes of a friend: changes in mood and behavior in early HD
Companions of HD gene carriers are more likely to notice psychological changes in presymptomatic HD.
By Dr Leora Fox -
New tool to measure outcomes in Huntington’s Disease clinical trials
A better tool for HD trials! New research shows innovative way to measure mutant Huntingtin outside the brain
By Megan Krench -
How long is too long? Rethinking the Huntington’s disease ‘gray area’
Does an ‘intermediate’ CAG repeat count in the Huntington’s disease gene cause brain changes?