immune-system
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Putting it in print: a clinical trial trying to rein in runaway pruning
⏱️10 min read | Four years after announcing positive results in their trial of ANX005 (tanruprubart) for HD, Annexon has formally published the results. It’s safe, hits its target, and may have helped some participants – so what’s the holdup?
By Dr Leora Fox -
Intruders in the Brain: What a Pig Model Reveals about Immune Cells in HD
⏱️7 min read | A recent study in pigs suggests the HD brain could be under attack from the body’s own immune system. The results reveal that invading cytotoxic T cells might contribute to neurodegeneration in HD, suggesting a new therapeutic pathway.
By AJ Keefe -
Disappointing news from LEGATO-HD trial of laquinimod in Huntington's disease
The LEGATO-HD trial of laquinimod did not slow progression of Huntington's disease. Here's the lowdown.
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Planting trees together: The 2016 Huntington's Disease Society of America Convention
HDBuzz summarizes the science from an unusually large and energized @HDSA convention in Baltimore
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Prominent Huntington's disease researcher "fabricated data" in grant applications
Noted Huntington's disease researcher found to have falsified data on grant applications – but published findings sta
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Calming down the immune system helps Huntington's disease mice
CB2-activating drug improves survival and symptoms in Huntington's disease mice through calming down the immune syste
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Bone marrow transplantation in Huntington's Disease
Bone marrow transplant protects HD mice from some symptoms, suggesting the immune system may be an important target