huntingtin-lowering – Page 5

What does COVID-19 mean for Huntington’s disease families and HD research?

COVID-19 update: what does it mean for HD families, how does it impact HD research, and how has it changed the way science works?

By Dr Sarah Hernandez & Professor Ed Wild, MRCP, PhD

April 6, 2020

Huntington’s disease therapeutics conference 2020 – Day 3

HDBuzz reports from the annual Huntington’s disease therapeutics conference in Palm Springs

By Dr Sarah Hernandez, Dr Rachel Harding & Joel Stanton

March 3, 2020

Unpacking Wave's PRECISION-HD2 huntingtin-lowering trial announcement

Wave Life Sciences announces that its antisense drug WVE-120102 has lowered mutant huntingtin protein in cerebrospinal fluid, but investors seem disappointed. Rather confusing – what do we know for sure?

By Dr Jeff Carroll, PhD

January 3, 2020

Could molecular handcuffs lower the protein that causes Huntington's disease?

Researchers got surprisingly lucky when looking for drug molecules to pull mutant huntingtin protein into a cellular garbage disposal machine

By Dr Tamara Maiuri

November 12, 2019

Exciting new Huntingtin lowering tool described

Exciting new Huntingtin Lowering work from @SangamoTx and @CHDIfoundation using "Zinc Fingers" to shut down expression of the mutant Huntingtin gene. More details on this exciting new technique here.

By Dr Jeff Carroll, PhD

August 5, 2019

Details emerge of first Huntington’s disease gene therapy clinical trial

UniQure announces key details of its planned trial to assess the safety and ability of AMT-130 gene therapy to lower the problematic huntingtin protein using a ‘single-shot’ virus delivery system.

By Dr Anna Pfalzer

July 17, 2019