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Putting it in print: a clinical trial trying to rein in runaway pruning
ā±ļø10 min read | Four years after announcing positive results in their trial of ANX005 (tanruprubart) for HD, Annexon has formally published the results. Itās safe, hits its target, and may have helped some participants ā so whatās the holdup?
By Dr Leora Fox -
Mirror, Mirror on the Wall: When Self-Awareness Shifts in Huntingtonās Disease
ā±ļø6 min read | A new study suggests that reduced awareness of symptoms, known as anosognosia, may appear even in the earliest stages of HD. The findings highlight that understanding symptom progression requires more than one perspective.
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More Than Just Food: The Hidden Challenges of Eating with Huntingtonās Disease
ā±ļø8 min read | People with Huntingtonās disease commonly experience unintended weight loss. A recent article identified the challenges around HDās impact on eating and weight maintenance, and explored how families and professionals navigate them.
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Dancing With a Stranger: Understanding Apathy in Huntingtonās Disease Through Caregivers
ā±ļø5 min read | Apathy in HD isnāt just ānot caring.ā It can affect relationships, routines, and emotional connection. A small study of caregivers reveals the heavy toll of apathy and the value of safe spaces to share experiences.
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Artificial Intelligence enters the HD space as a diagnostic tool
ā±ļø9 min read | From predicting symptom onset to tracking movement changes via smartwatch, artificial intelligence tools are being used in research. Here’s where we are, and why Huntingtonās disease is a strong candidate for these approaches.
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UniQure and FDA No Longer in Alignment on Approval Pathway for AMT-130
In a new press release, uniQure shared that the FDA no longer agrees with their approach for advancing AMT-130, specifically the use of an external control group. The path forward is uncertain, but uniQure remains committed to the HD community.
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How Big Is The Huntingtonās Disease Iceberg?
We can count how many people are seen in a clinic with Huntingtonās disease by genetic testing, but how many people with the gene for HD are never diagnosed by a doctor? A new mathematical approach seeks to revisit this tricky question.
By Dr Chris Kay -
Body in Decline: Muscle Loss as an Early Symptom of Huntingtonās Disease
Huntingtonās disease doesnāt just damage the brain, it also breaks down muscles and fat, and disrupts nutrition early on. New work suggests thereās a hidden physical decline in early HD, so monitoring body changes could help with better care.
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When the Brainās Orchestra Falls Out of Tune: A New Map of Huntingtonās Disease Progression
New research maps Huntingtonās disease progression like a symphony unraveling. The brain first overcommunicates, then loses sync, and finally falls silent, each stage driven by different biological mechanisms.
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Peeking at huntingtin and learning from a PET study
Scientists tested a new tool to measure harmful HTT protein in HD. It wasnāt perfect, but offered key insights to guide better tools already in the works. A big step toward tracking HD non-invasively, from inside the brain!
By Dr Leora Fox