genetics
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When interrupting is good: genetic hiccups that protect against Huntington's disease
Multiple teams find small differences in the 'CAG repeat' bit of the Huntington's disease gene. They don't directly change the huntingtin protein, but do alter the age of symptom onset. What's behind this enigma and what does it mean for patients?
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Huntington's disease therapeutics conference 2019 – Day 3
New insights into the huntingtin protein, and further progress in turning genetic quirks that modify the course of HD into treatments, on the final day of the therapeutics conference
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Kids sometimes get Huntington’s disease too
Finally, a big study that shows what childhood HD looks like. This will help us work out if new drugs work in children too
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Huntington's Disease Therapeutics Conference 2017 – Day 1
HDBuzz summarises all the science from the 2017 Huntington's Disease Therapeutics Conference in Malta – day 1
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Ultra-rare mutations highlight the importance of the HD gene in brain development
New technology enables researchers to find ultra-rare mutations in the HD gene, distinct from the one causing HD
By Megan Krench -
Important drug targets yielded by new genetic study of HD
A genetic study confirms that minute differences in DNA repair genes can influence the age of HD symptom onset.
By Dr Leora Fox -
Huntington's Disease Therapeutics Conference 2016 – day 1
Proteins and DNA – Jeff and Ed report from day 1 of the 2016 #huntingtonsdisease therapeutics conference
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Huge study reveals new 'genetic modifiers' of Huntington's disease
GeM-HD identifies the first solid leads in the hunt for genetic variations that affect Huntington's disease onset
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Switching it up: variety in the HD gene affects symptom onset
Variety in the HD gene’s on switch affects when symptoms arise.
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Building a Better Mouse(trap): A New Model of Huntington’s Disease
New mouse model gives insights into Huntington's disease