disease-modifying
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Could HD be caused by amino acid deficiency?
Does a specific amino acid deficiency contribute to the development of HD?
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Does high-dose creatine "slow the onset" of Huntington's Disease?
A new study claims that high-dose creatine "slows the onset of Huntington Disease". How much hope and how much hype?
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Prana Biotech publishes Huntington's disease animal model data for PBT2
Prana Biotechnology has released data demonstrating their drug, PBT2, is effective in animal models of HD
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ASO gene silencing reaches further, lasts longer
Silencing the Huntingtin gene using ASO drugs reaches further, lasts longer and is safe. Human trial soon?
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Double success for huntingtin RNAi gene silencing
2 bits of good news for RNAi gene silencing in HD: it's safe over six months, and a way to treat bigger brain areas
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New experiments clarify the role of SIRT1 in HD – or do they?
Work from multiple labs suggests activating a protein called SIRT1 might help HD, but the picture is still confusing
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Bone marrow transplantation in Huntington's Disease
Bone marrow transplant protects HD mice from some symptoms, suggesting the immune system may be an important target
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Melatonin treatment success in HD mice
Melatonin delays disease onset and extends survival in Huntington's disease mice – could it do the same for patients?
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HDAC inhibitors and a possible 'blood biomarker'
HDAC inhibitors explained, plus how new HDAC-related Huntington's disease research might help us find biomarkers
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Gene silencing takes a targeted step forward
Targeting the mutant Huntington's disease gene for silencing, while leaving the healthy gene untouched