development
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Huntington Study Group (HSG) 2020 Annual Conference: HD in Focus – Day 2
The 2020 virtual HSG conference HD in Focus continues on Day 2 with a focus on clinical trials and drugs in development.
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Working as a team: Changes in brain development mean some brain regions may be slacking off
Scientists use human fetal tissue to look at HD brain development. But what do developmental changes mean when symptoms don’t occur until decades after birth?
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The third dimension: using minibrains to understand brain development changes in HD
Researchers show that highly expanded CAGs in the HD gene can cause early developmental changes using 3D brain models called organoids. What’d they find?
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Fresh Updates from First Huntingtin Lowering Study Publication
Hot off the presses – New publication gives more details about the results of Ionis and Roche's safety study with a Huntingtin-lowering ASO
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The benefits of migration, highlighted in Huntington's disease
Is HD a developmental disease? HD stops neurons migrating in developing brain, but maybe we can get them going again
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Early exposure to the HD protein may cause life-long symptoms
A surprising new mouse study suggests the mutant HD gene may do some of its damage during embryonic development
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Does the HD mutation affect children's growth?
A small study suggests kids with the HD mutation but no symptoms have subtle differences in growth. What does it mean