cell-model
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Has a "wonder drug" for dementia been discovered? (Spoiler alert: no.)
Media reports of a wonder drug for neurodegenerative diseases like Huntington's disease are overhyped
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Enemy at the gates – huntingtin disrupts nuclear transport
Two recent studies show how a cellular border control system goes wrong in HD, opening new avenues for HD research.
By Tom Peskett -
Huntingtin grabs a hammer: DNA repair in HD
Huntingtin helps fix damaged DNA, a recent study suggests, under the direction of a gene repair protein called ATM.
By Dr Leora Fox -
Huntingtin takes a trip: harmful proteins pass between brain cells
Harmful misfolded huntingtin can travel between brain cells via messenger particles called exosomes
By Dr Leora Fox -
A Few Bad Seeds: Using Brain Fluid to Grow Clumps in Brain Cells
HD brain fluid makes brain cells grow clumps.
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Taking new targets to the bank: the DNA repair protein ‘ATM’ is overactive in Huntington's disease
HD causes the normally helpful protein "ATM" to get a little overzealous. Now we can look for drugs to settle it down
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Unlocking the Potential of Antibodies as a Therapy for Huntington’s Disease
Antibodies are known for their role in immunity, but researchers repurpose them in many ways. Can they be used in HD?
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Turning skin cells into brain cells: a Huntington's disease research breakthrough?
Scientists can now change human skin cells into working neurons, like the ones that are most affected in HD.
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NUB1: enhancing clearance to decrease mutant huntingtin
NUB1 increases mutant huntingtin removal from cells, reducing the toxic effects of HD in fruit flies
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Joint HDBuzz Prizewinner: Yeast studies suggest a new way to protect cells from 'oxidative damage'
Researchers identify Gpx1, a protein that may be protective in HD. An existing drug can mimic its antioxidant effect.
By Dr Leora Fox