cag-instability
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Regulating repetition: Gaining control of CAG repeats could slow progression of Huntington’s disease
8 min read
Many diseases are caused by repetitive DNA sequences. Understanding the regulation of those repetitive sequences may hold the key for unlocking therapeutics for Huntington’s disease. A team from Toronto has just advanced our understanding.
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Could halting CAG expansions be a new treatment for HD?
7 min read
The gene MSH3 is getting a lot of attention in HD research lately. New findings suggest MSH3 lowering could halt CAG repeat expansions, offering a new therapeutic avenue.
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Tipping the balance; new insights into HD genetic modifiers
5 min read
A new study from researchers at Thomas Jefferson University delves into the details of how genetic modifiers of Huntington’s disease work.
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BAC to basics: a more accurate mouse model for Huntington's disease
7 min read
A genetically-tweaked Huntington's disease mouse model shows a tendency for the CAG repeat to grow, just like we see in humans with the mutation.