cag-instability
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New Insights Into Why Huntingtonās Disease Has Delayed Onset
A highly-anticipated scientific paper has landed! This new work challenges current theories in Huntingtonās disease research, uncovering how runaway CAG repeats erode cell identity in certain types of brain cells, leading to their death.
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Spotting HD Early: The Clues Hidden in Young Brains
Researchers have detected early changes in brain scans and biomarkers in young people with the Huntingtonās disease gene, 20 years before symptoms are predicted to appear. These findings could help develop medicines to treat HD earlier in life.
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2024: Year in Review
As we begin 2025, we look back on all of the Huntingtonās disease research news and progress the field has made in the last 12 months.
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Two birds, one stone: HTT-lowering drugs also target CAG expansions
In a surprising twist, oral HTT-lowering drugs also slow somatic expansion in the HTT gene. A new study that used cells in a dish for this fortuitous discovery identified the gene PMS1 as a key player in the slowing of CAG expansions.
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Hats off to brain donors on Brain Donation Awareness Day
May 7 is Brain Donation Awareness Day. Today we highlight the selfless donation that many HD families have made, sending our gratitude, sharing research updates made with those precious brains, and detailing resources for brain donation.
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Understanding expansions at the single cell level
Scientists have looked at CAG expansions in brains from people with HD to see which cells are affected
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Regulating repetition: Gaining control of CAG repeats could slow progression of Huntingtonās disease
Many diseases are caused by repetitive DNA sequences. Understanding the regulation of those repetitive sequences may hold the key for unlocking therapeutics for Huntingtonās disease. A team from Toronto has just advanced our understanding.
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Could halting CAG expansions be a new treatment for HD?
The gene MSH3 is getting a lot of attention in HD research lately. New findings suggest MSH3 lowering could halt CAG repeat expansions, offering a new therapeutic avenue.
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Tipping the balance; new insights into HD genetic modifiers
A new study from researchers at Thomas Jefferson University delves into the details of how genetic modifiers of Huntingtonās disease work.
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BAC to basics: a more accurate mouse model for Huntington's disease
A genetically-tweaked Huntington's disease mouse model shows a tendency for the CAG repeat to grow, just like we see in humans with the mutation.