blood-brain-barrier
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2024: Year in Review
As we begin 2025, we look back on all of the Huntington’s disease research news and progress the field has made in the last 12 months.
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The VIP section: velvet ropes for the brain and how to get in
New work from two groups advances tools to model the blood-brain barrier and could improve the way drugs are delivered for brain diseases. This builds on our ability to study, and eventually treat, Huntington’s disease.
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Oral drug may change the story for huntingtin lowering
Researchers with PTC Therapeutics recently published exciting new findings – a promising new huntingtin lowering drug that can be taken as a pill. Will this change how we move forward with huntingtin lowering?
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Unpacking recent gene therapy press
Voyager Therapeutics is shifting towards a new technology to deliver gene therapy and away from a planned HD clinical trial. But this could lead to less invasive drugs in the long run, and many other companies are working on HD gene therapies.
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Harnessing the power of viruses to treat Huntington's disease
Researchers design a virus to more effectively deliver gene-silencing drugs throughout the brain.
By Dr Leora Fox -
A faulty filter? Blood vessel changes in Huntington's disease
New research reveals blood vessel changes that could contribute to problem in HD
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Could a 'brain shuttle' get Huntington's disease drugs to where they're needed?
Roche's 'brain shuttle' sneaks drugs past the blood-brain barrier. Could it work for HD gene silencing drugs?
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Targeting oxidative stress in Huntington's Disease
Damage to cells caused by oxidative stress is part of HD – could a new targeted drug help reduce this problem?
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KMO inhibitor drug improves lifespan of Huntington's disease mice
Positive results from tests of a new 'KMO inhibiting' drug in Huntington's disease mice