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Intruders in the Brain: What a Pig Model Reveals about Immune Cells in HD
Latest News
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Body in Decline: Muscle Loss as an Early Symptom of Huntingtonâs Disease
Huntingtonâs disease doesnât just damage the brain, it also breaks down muscles and fat, and disrupts nutrition early on. New work suggests thereâs a hidden physical decline in early HD, so monitoring body changes could help with better care.
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Appetite for Answers: Does Eating on a Schedule Help with Huntingtonâs Disease?
A new review explores whether time-restricted eating (TRE) could help manage Huntingtonâs disease (HD) by boosting brain health in animal models. While the science is exciting, there are real risks for people with HD.
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July 2025: This Month in Huntingtonâs Disease Research
Julyâs HD research roundup: Brain scans, gene editing, glial cells, and even smartphones reveal new ways to track and treat Huntingtonâs. From sleep to cell power, science is zooming in and bringing hope for earlier, smarter interventions.
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When the Brainâs Clock Breaks: Sleep Disruption and Circadian Chaos in Huntingtonâs Disease
A 12-year study reveals how disrupted sleep may predict Huntingtonâs disease onset, could link to changes in thinking and thought processing, and contribute to nerve damage. Sleep isnât just rest, itâs a vital brain process for brain health.
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Pridopidine Hits a Roadblock: EMA Says No to Approval for Huntingtonâs Disease Treatment
The EMA has rejected pridopidine for HD treatment in Europe. While disappointing, this outcome aligns with the trial data. Prilenia plans further studies, and despite setbacks, HD research in 2025 continues to bring momentum and hope.
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When the Brainâs Orchestra Falls Out of Tune: A New Map of Huntingtonâs Disease Progression
New research maps Huntingtonâs disease progression like a symphony unraveling. The brain first overcommunicates, then loses sync, and finally falls silent, each stage driven by different biological mechanisms.
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Stopping the Genetic Snowball: How a simple genetic interruption slows Huntingtonâs disease
The Huntington’s disease mutation worsens over time like a dangerous snowball. By harnessing the power of the gene editing tool CRISPR, scientists may have found a way to interrupt the HD mutation and stall disease onset.
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Cracking the Case: How a Smartphone âDetectiveâ is Helping Track Huntingtonâs Disease Progression
Smartphones can help scientists calculate a new clinical measure of HD, called the HD Digital Motor Score. Easier data collection could means less clinic trips, fewer people needed for studies, and a better understanding of HD.Â
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Unsung Heroes: Could Glial Cells Treat Huntingtonâs Disease?
Transplanting healthy human glial cells into HD mouse brains improved movement, memory, and survival. Even more strikingly, the glia coaxed diseased neurons to behave more like healthy ones, offering a potential new path for treating HD.
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Simon Says Stop: What a Childrenâs Game Can Teach Us About Early Huntingtonâs Disease
Simon Says isnât just a game, itâs a window into early HD! In this study, tiny thumb twitches reveal how attention slips before impulsivity kicks in. Understanding this could help catch HD sooner & improve support. Ready to play?
HDBuzz Trial Tracker
Sites for Phase 3 trial for votoplam, INVEST-HD, now open. Updates on recruitment and first dosing imminent.
REGEN4HD, Phase 1 stem cell implantation study commences
Progress update for NCT06585449 – A Study to Evaluate ALN-HTT02
