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2025: Year in Review
Latest News
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Break Up With Your CAGs: How Three Letters Could Change Huntington’s Disease
Scientists engineered stem cells with “interrupted” CAG repeats to break up the toxic stretch. This may stop expansion, and could improve problems in cells that model Huntington’s disease. This study suggests that DNA spelling can drive the disease.
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ASO gene silencing reaches further, lasts longer
Silencing the Huntingtin gene using ASO drugs reaches further, lasts longer and is safe. Human trial soon?
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Phosphodiesterase inhibitors: new HD drugs entering trials soon
CHDI and Pfizer announce exciting animal work and plans for a human trial with a drug targeting 'phosphodiesterases'.
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Interview: CHDI's scientific team
HDBuzz interviews the top scientists from CHDI, the largest funder of Huntington's disease research in the world.
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Exercise increases cellular recycling
Exercise boosts cellular recycling in mice. Could this be why exercise is also good for HD – or even help develop dru
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The HDBuzz Prize for young science writers
Announcing the HDBuzz Prize for young science writers!
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What's the connection between Huntington's Disease and cancer?
HD patients are less likely to get cancer, according to a study from Sweden – what does this mean?
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Closing the care gap: new guidelines for HD care
Closing the care gap: new guidelines to help every Huntington's disease patient get great care
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Stem-cell neurons make the right connections
Replacing neurons in mice with stem cells works much better than expected, suggesting that replacement therapy might
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2012 Therapeutics Conference: a retrospective
HDBuzz looks back at the 2012 Huntington's Disease Therapeutics Conference
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Mutant yeast highlights crucial CAG-reading protein
A new job for a DNA-reading protein called SPT4 – controlling the balance of mutant and healthy huntingtin protein
