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2025: Year in Review
Latest News
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Break Up With Your CAGs: How Three Letters Could Change Huntington’s Disease
Scientists engineered stem cells with “interrupted” CAG repeats to break up the toxic stretch. This may stop expansion, and could improve problems in cells that model Huntington’s disease. This study suggests that DNA spelling can drive the disease.
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A multiple sclerosis drug that works for Huntington's disease: the real deal or too good to be true?
Fingolimod, a drug used in multiple sclerosis, prevents memory problems in HD mice. Would it work in patients?
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Mapping the anatomy of HD: a whole-brain history
A new book for researchers describes a century of HD anatomy and presents evidence that HD affects the whole brain.
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Liftoff: First humans treated with gene silencing drugs for HD!
Major Announcement: First HD patients treated with gene silencing drugs
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HDBuzz primer: Clinical trial designs and phases
HDBuzz untangles hope from hype in clinical trial announcements
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A Few Bad Seeds: Using Brain Fluid to Grow Clumps in Brain Cells
HD brain fluid makes brain cells grow clumps.
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New tool to measure outcomes in Huntington’s Disease clinical trials
A better tool for HD trials! New research shows innovative way to measure mutant Huntingtin outside the brain
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Huge study reveals new 'genetic modifiers' of Huntington's disease
GeM-HD identifies the first solid leads in the hunt for genetic variations that affect Huntington's disease onset
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Would ewe believe it? GM1, sheep and Huntington's disease
HD researchers and sheep farmers are collaborating on a brain fat called GM1, but a clinical trial is a long way off
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Switching it up: variety in the HD gene affects symptom onset
Variety in the HD gene’s on switch affects when symptoms arise.
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Measuring harmful huntingtin protein in the brain’s bath water
How will we know whether HD-lowering treatments are working? New advancements in the detection of mutant huntingtin.
