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Additional Clarity: What We Know 4 Weeks After the uniQure News
Latest News
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The Gut–Brain Superhighway in Huntington’s Disease: Clues From the Microbes Inside Us
The gut and brain are connected by a busy two-way superhighway. In Huntington’s disease, traffic on this road may be jammed, detoured, or carrying harmful cargo, linking gut microbes, inflammation, and brain health in surprising ways.
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Carried from Childhood: Childhood Experiences and Adult Mental Health in Families with Huntington’s Disease
Some childhood experiences stay with us, quietly shaping how we feel as adults. For those raised in families with Huntington’s disease, this new study helps make sense of those feelings, and reminds us that healing is possible.
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Body in Decline: Muscle Loss as an Early Symptom of Huntington’s Disease
Huntington’s disease doesn’t just damage the brain, it also breaks down muscles and fat, and disrupts nutrition early on. New work suggests there’s a hidden physical decline in early HD, so monitoring body changes could help with better care.
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Appetite for Answers: Does Eating on a Schedule Help with Huntington’s Disease?
A new review explores whether time-restricted eating (TRE) could help manage Huntington’s disease (HD) by boosting brain health in animal models. While the science is exciting, there are real risks for people with HD.
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July 2025: This Month in Huntington’s Disease Research
July’s HD research roundup: Brain scans, gene editing, glial cells, and even smartphones reveal new ways to track and treat Huntington’s. From sleep to cell power, science is zooming in and bringing hope for earlier, smarter interventions.
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When the Brain’s Clock Breaks: Sleep Disruption and Circadian Chaos in Huntington’s Disease
A 12-year study reveals how disrupted sleep may predict Huntington’s disease onset, could link to changes in thinking and thought processing, and contribute to nerve damage. Sleep isn’t just rest, it’s a vital brain process for brain health.
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Pridopidine Hits a Roadblock: EMA Says No to Approval for Huntington’s Disease Treatment
The EMA has rejected pridopidine for HD treatment in Europe. While disappointing, this outcome aligns with the trial data. Prilenia plans further studies, and despite setbacks, HD research in 2025 continues to bring momentum and hope.
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When the Brain’s Orchestra Falls Out of Tune: A New Map of Huntington’s Disease Progression
New research maps Huntington’s disease progression like a symphony unraveling. The brain first overcommunicates, then loses sync, and finally falls silent, each stage driven by different biological mechanisms.
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Stopping the Genetic Snowball: How a simple genetic interruption slows Huntington’s disease
The Huntington’s disease mutation worsens over time like a dangerous snowball. By harnessing the power of the gene editing tool CRISPR, scientists may have found a way to interrupt the HD mutation and stall disease onset.
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Cracking the Case: How a Smartphone “Detective” is Helping Track Huntington’s Disease Progression
Smartphones can help scientists calculate a new clinical measure of HD, called the HD Digital Motor Score. Easier data collection could means less clinic trips, fewer people needed for studies, and a better understanding of HD.Â