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2025: Year in Review
Latest News
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Break Up With Your CAGs: How Three Letters Could Change Huntington’s Disease
Scientists engineered stem cells with “interrupted” CAG repeats to break up the toxic stretch. This may stop expansion, and could improve problems in cells that model Huntington’s disease. This study suggests that DNA spelling can drive the disease.
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HDSA’s Q&A on the latest huntingtin-lowering update from Ionis and Roche
Our friends at @hdsa have produced this really good Q&A document about the latest huntingtin-lowering news.
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Exciting Experiments in "Open Science" by Huntington's Researchers
Brave scientists open their notebooks to help drive HD research at the risk of getting "scooped".
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The structure of the protein that causes Huntington's disease, revealed
Huntingtin protein's structure is now clear thanks to cryo-electron microscopy. This is kind of a big deal
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Huntington's disease therapeutics conference 2018 – day 3
Updates from day 3 of the Huntington’s Disease Therapeutics Conference: huntingtin protein – and lowering it
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Huntington's disease therapeutics conference 2018 – day 2
DNA takes centre stage for day 2 of the Huntington's Disease Therapeutics Conference in Palm Springs
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Huntington's disease therapeutics conference 2018 – day 1
Our daily roundup of the science presented at the 2018 HD Therapeutics Conference in Palm Springs
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An early role for the Huntington's disease gene – but don't believe all the headlines
A surprising new paper sheds light on the role of the HD gene early in development. Should we worry?
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New interest in an old target
Promising results in mice provide renewed optimism for mGluR5 antagonists
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Ask the expert: Q&A on the huntingtin-lowering trial program
In a Q&A coordinated by the UK HD Association, Dr Ed Wild answers questions on the recently-announced trial
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Success! ASO drug reduces levels of mutant protein in Huntington's disease patients
Amazing news from Ionis and Roche! HTTRx drug successfully lowers harmful huntingtin protein in spinal fluid
