cognition
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Inside the Brainās Theme Park: How Huntingtonās Disease Disrupts the Emotion Coaster
Welcome to Brainland, the bustling, 24/7 theme park in your head. Thereās Memory Maze, Logic Log Flume, and of course, the Emotion Coaster, where your brain races through tracks themed around happiness, sadness, and anger. However, for some people who carry the gene for Huntingtonās disease (HD), some of these rides start acting up long…
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One Disease, Many Paths: How Brain Wiring Shapes Huntingtonās Symptoms
HD starts with a single gene change, but its effects travel many roads. New work shows how brain networks breakdown or reroute. Whether movement, thinking, or mood are most affected, we may be able to guide care in a more personalized direction.
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Stars in the Sky: Psychosis in Huntingtonās Disease
New research shines a light on an often-overlooked side of Huntingtonās diseaseāpsychosis. Understanding the impact of psychosis on daily life and progression of other HD symptoms could be key to providing better care and support.
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Do Antidepressants Affect Cognitive Decline? There's More To The Story For Huntington's Disease
Recent research suggests a connection between antidepressant use and increased cognitive decline in people with dementia. However these finding shouldn't be blindly applied to Huntington's disease.
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Brain Gym: Staying Mentally Active May Slow Huntingtonās Disease
New research suggests that cognitive engagement – keeping your brain busy with activities like reading, puzzles, or learning new skills – could help protect the brain, possibly slowing progression of symptoms of Huntingtonās disease.
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The dust has settled: Sageās dalzanemdor wonāt advance for cognitive impairment
Changes in thinking, learning, and memory are some of the most distressing and impactful in Huntingtonās disease. Sage Therapeutics was advancing their drug dalzanemdor to treat these symptoms, but unfortunately this program will be halted.
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14 changes for a healthier brain
In 2019, there were ~57 million people living with dementia. By 2050, that number is expected to climb to 153 million. Changes in the 14 factors highlighted here can improve brain health and be applied to Huntingtonās disease.
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SURVEYOR opens the door for drugs that treat cognition
Sage Therapeutics announced results from SURVEYOR, a trial that looked at cognitive changes in people with HD, and tested short-term safety of dalzanemdor. The study was small but met key goals, and additional trials are in progress.
By Dr Leora Fox -
HD Young Adult Study defines the sweet spot: symptom-free with measurable changes
We know that HD-related changes can occur many years before symptom onset, but how early do those changes begin? A team of researchers set out to determine that with a new comprehensive study in pre-manifest HD young adults.
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Thinking clearly about the earliest symptoms of HD and which brain regions control them
HD reaches more brain structures than we thought: new research broadens our understanding of the earliest signs of HD