Huntington’s disease research news. In plain language. Written by scientists. For the global HD community.

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Articles with the topic: cilia

The 'N17' region of huntingtin protein: an address label in Huntington's disease?

The 'N17' region of huntingtin protein: an address label in Huntington's disease?

Joseph Ochaba on February 26, 2013

New research is helping understand how the mutant huntingtin protein moves around the cell. Discovering where huntingtin ends up, and why, could help us understand HD. Now, Canadian researchers have shown that a small piece of the huntingtin protein behaves like an 'address label' for the whole protein. By studying this label and how it affects Huntington's disease symptoms, we may be able to better understand what goes wrong in HD and hopefully generate a disease-modifying therapy.

HD just got cilia

HD just got cilia

Dr Jeff Carroll on October 11, 2011

A better understanding of the normal role of the huntingtin protein would make developing treatments easier. Surprising new results from French researchers suggest that huntingtin influences tiny hair-like structures called 'cilia'. Now we need to figure out what it means for patients.