Huntington’s disease research news. In plain language. Written by scientists. For the global HD community.

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Latest news

Turning skin cells into brain cells: a Huntington's disease research breakthrough?

Turning skin cells into brain cells: a Huntington's disease research breakthrough?

Lakshini Mendis on November 27, 2014

Scientists can now reprogram human skin cells to make working cells that resemble 'medium spiny neurons', the type of brain cell that is most affected early in Huntington's disease. We're still a long way off from being able to replace the brain cells that are being lost in HD, but this research is an important step down that path, and is a great tool to study HD.

Huntington's disease clinical trial announcement: huntingtin-lowering drug to enter Phase I trial in 2015

Huntington's disease clinical trial announcement: huntingtin-lowering drug to enter Phase I trial in 2015

Leora Fox on November 04, 2014

A new clinical trial just announced for 2015 aims to test a “huntingtin lowering” therapy, called an antisense oligonucleotide (ASO), that attacks mutant huntingtin directly. We’re extremely excited—it’s the first-ever human HD trial to fight HD at the root of the problem, and has shown great promise in animal models. What’s the scoop?

Largest creatine clinical trial for Huntington's disease halted after 'futility' analysis

Largest creatine clinical trial for Huntington's disease halted after 'futility' analysis

Dr Ed Wild on October 29, 2014

CREST-E, the largest clinical trial of the dietary supplement creatine, has been terminated early because an early analysis of the results to date showed there was no realistic chance it could show positive results. This provides compelling evidence that creatine doesn't slow down progression in Huntington's disease patients.

Should we worry about a huntingtin invasion?

Should we worry about a huntingtin invasion?

Dr Jeff Carroll on October 27, 2014

New work in brain diseases like Alzheimer's suggests that brain cells called neurons might be 'catching' the sickness from their neighbors. A recently published paper suggests that, in very specific lab conditions, this might also happen in Huntington's disease. What does this mean for what we know about HD, and how to treat it?

EuroBuzz 2014 Video, day one

EuroBuzz 2014 Video, day one

Dr Ed Wild on October 10, 2014

We present the video of Ed and Jeff's review of first day's science at the European HD Network meeting in Barcelona.

EuroBuzz 2014 Video, day two

EuroBuzz 2014 Video, day two

Dr Jeff Carroll on October 10, 2014

Ed and Jeff present the second day's science at the EHDN meeting in Barcelona. Features a clinical trials roundup, an exclusive interview with Prof Sarah Tabrizi about the first trial of a huntingtin lowering 'gene silencing' drug, and a surprise for EHDN president Prof Bernhard Landwehrmeyer.

Melatonin alterations in Huntington's disease help explain trouble with sleep

Melatonin alterations in Huntington's disease help explain trouble with sleep

Leora Fox on October 07, 2014

Many people with Huntington's disease have problems sleeping. Sleep-wake cycles are controlled in part by melatonin, a hormone that makes you drowsy at bedtime. Scientists in London measured melatonin levels in HD patients, gene carriers, and unaffected individuals and found changes in the levels and timing of melatonin release. This could help to explain the sleep disruptions that occur in HD.

EuroBuzz 2014: day three

EuroBuzz 2014: day three

Dr Ed Wild on September 21, 2014

Our final report from the European HD Network meeting. For the first time, video of many presentations, including our 'EuroBuzz' sessions will be made available online shortly.

EuroBuzz 2014: day two

EuroBuzz 2014: day two

Dr Jeff Carroll on September 20, 2014

Here's Ed and Jeff's live Twitter report from the second day of the EHDN 2014 meeting. Our final report will be tomorrow, and we'll be uploading video of our onstage roundup sessions soon.