Huntington’s disease research news. In plain language. Written by scientists. For the global HD community.

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Raptor announces results of cysteamine trial for Huntington's disease

Raptor announces results of cysteamine trial for Huntington's disease

Dr Jeff Carroll on April 10, 2014

A chemical called cysteamine has long been of interest as a potential therapy for Huntington's disease. Now, Raptor Pharmaceuticals has announced the interim results of a study of cysteamine in HD patients. The trial failed to meet its pre-specified goal, but there are some interesting details in the data suggesting the ongoing trial deserves attention.

Sleep, cilia and HD

Sleep, cilia and HD

Graham Easton on March 06, 2014

Studies have shown that HD patients tend to get less efficient sleep, fewer hours of sleep, and wake up more times during the night. However, sleep in Huntington’s is under-researched because historically scientists have investigated HD as a disease of movement impairment, and sleep problems don’t seem to have anything to do with movement impairment.

Huntington's Disease Therapeutics Conference 2014: day 3

Huntington's Disease Therapeutics Conference 2014: day 3

Dr Ed Wild on February 28, 2014

Our final reports from the Huntington's disease therapeutics conference in Palm Springs.

Huntington's Disease Therapeutics Conference 2014: day 2

Huntington's Disease Therapeutics Conference 2014: day 2

Dr Jeff Carroll on February 27, 2014

HDBuzz reports from the second day of science at the Huntington's disease therapeutics conference in Palm Springs.

Huntington's Disease Therapeutics Conference 2014: day 1

Huntington's Disease Therapeutics Conference 2014: day 1

Dr Ed Wild on February 26, 2014

The Huntington's Disease Therapeutics Conference, held annually, is the biggest meeting of scientists working towards treatments for HD. Here's our report from the opening day of science sessions at the Conference.

Prana announces results of Reach2HD trial of PBT2 for Huntington's disease

Prana announces results of Reach2HD trial of PBT2 for Huntington's disease

Dr Jeff Carroll on February 20, 2014

The results are in from the Reach2HD study, which was designed to test the experimental drug PBT2 for early and mid-stage Huntington's disease. The drug seems safe and well-tolerated at the doses that were tested, but we have major concerns about the way the results have been reported.

Does high-dose creatine "slow the onset" of Huntington's Disease?

Does high-dose creatine "slow the onset" of Huntington's Disease?

Dr Jeff Carroll on February 11, 2014

The results of a new study called PRECREST, investigating whether the nutritional supplement creatine can slow Huntington's disease progression, have just been published. Uniquely, this studied the effects of high-dose creatine supplementation in people carrying the HD mutation, but without clear disease symptoms.

Joint HDBuzz Prizewinner: Yeast studies suggest a new way to protect cells from 'oxidative damage'

Joint HDBuzz Prizewinner: Yeast studies suggest a new way to protect cells from 'oxidative damage'

Leora Fox on February 05, 2014

Many types of stresses occur within cells that have the HD gene, and examining how simple organisms cope can help scientists define new targets for HD drugs. A new study examines yeast to determine which proteins can protect these cells from damage and death, uncovering a protective antioxidant and a related drug.

Joint HDBuzz Prizewinner: Pennies for your neurons — copper’s bad influence on Huntington’s disease

Joint HDBuzz Prizewinner: Pennies for your neurons — copper’s bad influence on Huntington’s disease

Terry Jo Bichell on January 30, 2014

Copper, the metal, may play a role in worsening the symptoms of Huntington’s disease. Bing Zhou and his team looked for connections between HD and the amount of copper in neurons. They report that reducing copper in neurons or keeping it from binding to the HD protein improves symptoms.