Huntington’s disease research news. In plain language. Written by scientists. For the global HD community.

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Articles with the topic: oxidative-stress

Novel research technique suggests an antioxidant gene protects vulnerable neurons

Novel research technique suggests an antioxidant gene protects vulnerable neurons

Leora Fox on April 06, 2015

Researchers have developed a new technique that allows them to screen for genes that could contribute to the progression of Huntington’s disease and other neurodegenerative disorders. This is the first time this is possible in the mammalian central nervous system. They used the technique in an HD mouse to uncover an antioxidant gene, Gpx6, which is protective to neurons.

Joint HDBuzz Prizewinner: Yeast studies suggest a new way to protect cells from 'oxidative damage'

Joint HDBuzz Prizewinner: Yeast studies suggest a new way to protect cells from 'oxidative damage'

Leora Fox on February 05, 2014

Many types of stresses occur within cells that have the HD gene, and examining how simple organisms cope can help scientists define new targets for HD drugs. A new study examines yeast to determine which proteins can protect these cells from damage and death, uncovering a protective antioxidant and a related drug.

Proposed Huntington's disease 'biomarker' is not useful, new study suggests

Proposed Huntington's disease 'biomarker' is not useful, new study suggests

Dr Jeff Carroll on April 25, 2013

A specific kind of damage called 'oxidative stress' may contribute to cells getting sick and dying in Huntington's disease. Previous reports had suggested that blood levels of a chemical marker of oxidative stress could be a 'biomarker' for HD clinical trials. But a newly-published work strongly suggests that it isn't a useful biomarker after all. Is this bad news?