Huntington’s disease research news. In plain language. Written by scientists. For the global HD community.

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Articles with the topic: blood-brain-barrier

Harnessing the power of viruses to treat Huntington's disease

Harnessing the power of viruses to treat Huntington's disease

Leora Fox on February 03, 2016

New therapies for disorders like Huntington’s disease are on the way, but getting the drugs to enter brain cells can be a major challenge. A group of scientists has redesigned and tested a harmless virus that can efficiently deliver a 'gene silencing' message throughout the brain in mice, much further than naturally occurring viruses can reach. What's more, it can be given with a simple injection into the blood, offering great potential for research in gene silencing research and beyond.

A faulty filter? Blood vessel changes in Huntington's disease

A faulty filter? Blood vessel changes in Huntington's disease

Melissa Christianson on May 13, 2015

Because brain cell death drives symptoms in Huntington’s disease, these cells steal the spotlight in disease-related research. But new research on the brain's blood supply has uncovered changes in HD that could be making it harder for the brain cells to cope with the disease.

Could a 'brain shuttle' get Huntington's disease drugs to where they're needed?

Could a 'brain shuttle' get Huntington's disease drugs to where they're needed?

Dr Jeff Carroll on January 20, 2014

Pharmaceutical giant Roche recently described a new drug delivery technology they call the 'brain shuttle'. Why has Huntington's disease been mentioned in so many press releases about this technology, and how much can we hope to gain from this new advance?

Targeting oxidative stress in Huntington's Disease

Targeting oxidative stress in Huntington's Disease

Dr Jeff Carroll on December 03, 2012

Some Huntington's disease researchers believe that drugs protecting against 'oxidative damage' could help HD patients. Existing drugs come with some problems, so a team of scientists have tested a new drug in a mouse model of HD, with encouraging early results.

KMO inhibitor drug improves lifespan of Huntington's disease mice

KMO inhibitor drug improves lifespan of Huntington's disease mice

Dr Ed Wild on June 02, 2011

An enzyme called KMO, which alters the balance of harmful and protective brain chemicals, has been a focus of research into possible Huntington's disease treatments for several years. Now, the first positive results of a KMO inhibiting drug have been published in the scientific journal Cell. HDBuzz investigates...