Update confirms Huntington's disease 'gene silencing' trial on track

Update confirms Huntington's disease 'gene silencing' trial on track

Ionis says its trial of HTTRx, intended to lower huntingtin protein, is fully recruited and plans to extend it

Dr Jeff CarrollOctober 15, 2017

New roles for huntingtin: removing a healthy protein to understand its function

New roles for huntingtin: removing a healthy protein to understand its function

Completely removing normal huntingtin in adults may disrupt healthy brain function, a recent study suggests.

Leora FoxSeptember 26, 2017

Precision huntingtin-lowering drug trials target the mutant protein

Precision huntingtin-lowering drug trials target the mutant protein

WAVE Life Sciences launches PRECISION clinical trial to suppress the mutant Huntington's disease protein

Dr Michael FlowerAugust 25, 2017

A step forward for gene editing: CRISPR-Cas9 and HD

A step forward for gene editing: CRISPR-Cas9 and HD

Evolving CRISPR-Cas9 techniques can now be used to edit the HD gene in a living mouse brain.

Leora FoxJuly 26, 2017

New study reveals a potential HD biomarker

New study reveals a potential HD biomarker

A potential HD biomarker has been uncovered in a recent clinical study

Leora FoxJune 07, 2017

Has a "wonder drug" for dementia been discovered? (Spoiler alert: no.)

Has a "wonder drug" for dementia been discovered? (Spoiler alert: no.)

Media reports of a wonder drug for neurodegenerative diseases like Huntington's disease are overhyped

Dr Michael FlowerMay 07, 2017

Huntington's Disease Therapeutics Conference 2017 - Day 3

Huntington's Disease Therapeutics Conference 2017 - Day 3

HDBuzz summarises final day of the 2017 Huntington's Disease Therapeutics Conference in Malta

Dr Ed WildApril 30, 2017

Huntington's Disease Therapeutics Conference 2017 - Day 2

Huntington's Disease Therapeutics Conference 2017 - Day 2

HDBuzz summarises all the science from the 2017 Huntington's Disease Therapeutics Conference in Malta - day 2

Dr Jeff CarrollApril 29, 2017

Huntington's Disease Therapeutics Conference 2017 - Day 1

Huntington's Disease Therapeutics Conference 2017 - Day 1

HDBuzz summarises all the science from the 2017 Huntington's Disease Therapeutics Conference in Malta - day 1

Dr Jeff CarrollApril 27, 2017

Enemy at the gates – huntingtin disrupts nuclear transport

Enemy at the gates – huntingtin disrupts nuclear transport

Two recent studies show how a cellular border control system goes wrong in HD, opening new avenues for HD research.

Tom PeskettApril 21, 2017

FDA approves a new drug for symptoms of Huntington's disease

FDA approves a new drug for symptoms of Huntington's disease

Deutetrabenazine becomes the first new drug in a decade licensed by the FDA for symptoms of Huntington's disease

Dr Jeff CarrollApril 05, 2017