Huntington’s disease research news. In plain language. Written by scientists. For the global HD community.

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Articles with the topic: human

What's the connection between Huntington's Disease and cancer?

What's the connection between Huntington's Disease and cancer?

Dr Jeff Carroll on April 25, 2012

Amongst the general population, cancer is one of the most feared killers. HD families might be forgiven for not thinking much about cancer, given the more obvious clear and present danger. But it turns out that there might be a connection between the mutation that causes HD and the risk of developing cancer, which could help us understand both conditions.

Huntexil update: EMA asks for further trial

Huntexil update: EMA asks for further trial

Dr Ed Wild on June 06, 2011

In April, the American drug regulator told NeuroSearch it would need a further large clinical trial before its Huntington's disease symptom-control drug Huntexil would be licensed. Now the European regulator, the EMA, has said the same for European licensing.

Improving Huntington's disease clinical trial recruitment through patient and family education

Improving Huntington's disease clinical trial recruitment through patient and family education

Dr Jeff Carroll on May 12, 2011

Trials of new treatments for Huntington's disease are happening, but proving whether a drug works requires lots of suitable volunteers. Surprisingly, finding enough volunteers is often difficult. Now a group of HD professionals has shown that education and outreach to patients in the community works well for boosting recruitment.

The genetic 'gray area' of Huntington's disease: what does it all mean?

The genetic 'gray area' of Huntington's disease: what does it all mean?

Dr Nayana Lahiri on April 22, 2011

By popular request, a special feature article on the often confusing topic of 'intermediate alleles' and 'reduced penetrance' – the genetic 'gray area' that frequently comes up in discussions around genetic testing for Huntington's disease.

Dimebon fails in late-stage human HD clinical trial

Dimebon fails in late-stage human HD clinical trial

Dr Jeff Carroll on April 11, 2011

Dimebon, an experimental drug marketed by Medivation, fails to improve the symptoms of Huntington’s disease patients in the HORIZON trial. This is the end of the road for developing this drug for HD.

FDA: further trial needed for Huntexil approval in HD

FDA: further trial needed for Huntexil approval in HD

Dr Jeff Carroll on April 04, 2011

NeuroSearch, the developer of experimental Huntington's disease drug Huntexil, has reported on their meeting with the FDA. The FDA requires that another trial be conducted before Huntexil could be approved in the US.

Successful gene therapy trial in Parkinson’s Disease gives hope for HD

Successful gene therapy trial in Parkinson’s Disease gives hope for HD

Dr Jeff Carroll on March 31, 2011

Scientists have successfully used viruses to deliver genes to the brains of Parkinson’s Disease patients. The gene carried by the viruses improved the movement symptoms of patients receiving injections. This proves that gene therapy in the brain can work, providing hope for similar therapies in HD.

An active lifestyle may make a difference to HD symptoms

An active lifestyle may make a difference to HD symptoms

Deepti Babu on January 10, 2011

We all know that exercise and staying active are good for everyone, whether or not they are at risk of developing HD. A new study of lifestyle activities in people with the HD mutation suggests that staying active is even more important in HD, and that passive habits – especially during the teenage years – might be one factor that can cause earlier onset of HD symptoms.

Dimebon: disappointing in Alzheimer’s but might work in HD

Dimebon: disappointing in Alzheimer’s but might work in HD

Dr Jeff Carroll on December 23, 2010

Dimebon, a drug developed in Russia as an anti-allergy medication, is under investigation as a possible treatment to improve thinking problems in HD. There was disappointment when a recent large trial of Dimebon to treat Alzheimer’s disease in the USA showed no benefit, but hope remains in HD where the DIMOND trial is continuing across Europe.