Huntington’s disease research news. In plain language. Written by scientists. For the global HD community.

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Articles with the topic: featured

Could HD be caused by amino acid deficiency?

Could HD be caused by amino acid deficiency?

Dr Jeff Carroll on April 21, 2014

All the proteins in our body are made of tiny chemical building blocks, called amino acids. The internet was recently buzzing about a newly discovered link between one of these amino acids, cysteine, and Huntington's Disease. Is it true, as some headlines suggested, that "Brain Degeneration In Huntington’s Disease Caused By Amino Acid Deficiency"?

Sleep, cilia and HD

Sleep, cilia and HD

Graham Easton on March 06, 2014

Studies have shown that HD patients tend to get less efficient sleep, fewer hours of sleep, and wake up more times during the night. However, sleep in Huntington’s is under-researched because historically scientists have investigated HD as a disease of movement impairment, and sleep problems don’t seem to have anything to do with movement impairment.

Prana announces results of Reach2HD trial of PBT2 for Huntington's disease

Prana announces results of Reach2HD trial of PBT2 for Huntington's disease

Dr Jeff Carroll on February 20, 2014

The results are in from the Reach2HD study, which was designed to test the experimental drug PBT2 for early and mid-stage Huntington's disease. The drug seems safe and well-tolerated at the doses that were tested, but we have major concerns about the way the results have been reported.

Does high-dose creatine "slow the onset" of Huntington's Disease?

Does high-dose creatine "slow the onset" of Huntington's Disease?

Dr Jeff Carroll on February 11, 2014

The results of a new study called PRECREST, investigating whether the nutritional supplement creatine can slow Huntington's disease progression, have just been published. Uniquely, this studied the effects of high-dose creatine supplementation in people carrying the HD mutation, but without clear disease symptoms.

Joint HDBuzz Prizewinner: Yeast studies suggest a new way to protect cells from 'oxidative damage'

Joint HDBuzz Prizewinner: Yeast studies suggest a new way to protect cells from 'oxidative damage'

Leora Fox on February 05, 2014

Many types of stresses occur within cells that have the HD gene, and examining how simple organisms cope can help scientists define new targets for HD drugs. A new study examines yeast to determine which proteins can protect these cells from damage and death, uncovering a protective antioxidant and a related drug.

Joint HDBuzz Prizewinner: Pennies for your neurons — copper’s bad influence on Huntington’s disease

Joint HDBuzz Prizewinner: Pennies for your neurons — copper’s bad influence on Huntington’s disease

Terry Jo Bichell on January 30, 2014

Copper, the metal, may play a role in worsening the symptoms of Huntington’s disease. Bing Zhou and his team looked for connections between HD and the amount of copper in neurons. They report that reducing copper in neurons or keeping it from binding to the HD protein improves symptoms.

What the 'big neurodegeneration breakthrough' means for Huntington's disease

What the 'big neurodegeneration breakthrough' means for Huntington's disease

Eric Minikel on October 15, 2013

Many people in the Huntington's disease community have noticed reports highlighting a recent study from the University of Leicester, which the BBC claimed "could treat Alzheimer's, Parkinson's, Huntington's and other diseases". The underlying study is well-executed research of some importance. However, the press hype is out of all proportion to the impact of this research. What does this study actually show, and what does it mean for HD?

Buzzilia Video: Day 1

Buzzilia Video: Day 1

Dr Jeff Carroll on October 09, 2013

We present Buzzilia, video 1: news highlights and in-depth interviews with top HD researchers from the World Congress on Huntington's disease 2013 in Rio de Janeiro. On the opening day of the Congress, Jeff and Ed review the major developments since the last World Congress in 2011, and talk to Prof Elena Cattaneo from Milan, Italy, about the huntingtin protein.

Video feature: Huntington's disease research... in space!

Video feature: Huntington's disease research... in space!

Dr Ed Wild on September 27, 2013

The huntingtin protein, which in its mutant form causes Huntington's disease, is difficult to study because it forms clumps rather than neat crystals. Now, young HD researcher Gwen Owens of California Institute of Technology is reaching VERY high to try to crack the problem. In a special video interview screened at the recent HD World Congress, HDBuzz spoke to Gwen about her 'out-of-this-world' plans...