Huntington’s disease research news. In plain language. Written by scientists. For the global HD community.

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Articles with the topic: rna-translation

Splicing with danger: a new way of thinking about the harmful Huntington's disease protein

Splicing with danger: a new way of thinking about the harmful Huntington's disease protein

Dr Tamara Maiuri on May 06, 2013

Researchers are hard at work figuring out exactly how the expanded Huntington's disease gene causes harm. Recent work from a UK group has uncovered another clue to help solve the mystery. It turns out that faulty processing of the huntingtin 'recipe' produces a short, harmful fragment of the huntingtin protein.

Lost in translation? New insights into the making of the Huntington's disease protein

Lost in translation? New insights into the making of the Huntington's disease protein

Melissa Christianson on April 01, 2013

Everyone has two copies of the huntingtin gene but Huntington's disease is caused by a copy that's extra-long. New research shows that cells have different controls for how the normal and extra-long instructions are used to make protein. These controls on the protein-making process may be targets for developing drugs for HD.