Huntington’s disease research news. In plain language. Written by scientists. For the global HD community.

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Articles with the topic: zinc-finger-nucleases

Giving Huntington's disease the finger? Two teams report success for zinc-finger drugs in cells and mice

Giving Huntington's disease the finger? Two teams report success for zinc-finger drugs in cells and mice

Dr Ed Wild on November 01, 2012

Designing drugs that tell our cells to make less of the harmful mutant huntingtin protein is one of the most promising approaches to treating Huntington's disease. Most huntingtin-lowering attempts so far have tried to 'shoot the messenger' rather than attacking the source of the message - the DNA itself. Now, two independent reports of success in HD mice have given a boost to 'zinc finger' drugs - which interact directly with the HD gene itself. It's early days for this new technology: what do we know, and what challenges are ahead?

Cut-and-paste DNA: fixing mutations with 'genome editing'

Cut-and-paste DNA: fixing mutations with 'genome editing'

Dr Jeff Carroll on July 18, 2011

What if we could edit the DNA of patients to remove the Huntington's disease mutation altogether? Sounds like science fiction, but new research in an animal model of hemophilia suggests that it can work - and now HD researchers are on the case.