Huntington’s disease research news. In plain language. Written by scientists. For the global HD community.

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Articles with the topic: development

The benefits of migration, highlighted in Huntington's disease

The benefits of migration, highlighted in Huntington's disease

Dr Michael Flower on February 10, 2017

Huntingtin, the protein responsible for Huntington’s disease, is fundamentally important for fetuses to develop in the womb, but we don’t know yet exactly what part it plays in this intricate process. Normally, neurons start life deep within the developing brain, migrate out to the surface and then make a network of connections with others, but Sandrine Humbert’s group showed that those without huntingtin get stuck, never making it to where they need to go. Neurons with mutated huntingtin are no better than those that lack it completely. However, reintroducing normal huntingtin, or the proteins through which it acts, allows neurons to migrate normally again, offering tantalising new ways to treat Huntington’s disease.

Early exposure to the HD protein may cause life-long symptoms

Early exposure to the HD protein may cause life-long symptoms

Mr. Shawn Minnig on June 28, 2016

When the ‘healthy’ HD gene functions as it should, one of its many jobs is in the development of normal embryos. Researchers have long assumed that the ‘mutant’ HD gene inherited by people with HD is still able to do this job, since HD patients develop normally and don’t show signs until later in life. A surprising new finding suggests we may have to think carefully about this assumption!

Does the HD mutation affect children's growth?

Does the HD mutation affect children's growth?

Dr Ed Wild on August 07, 2012

The huntingtin gene and protein are active throughout our bodies, and weight loss is a well-known problem once symptoms of Huntington's disease begin. Yet for many years, people with the mutation that causes HD, look and feel the same as people without it. Now a small study suggests that children carrying the HD mutation may have subtle differences in growth. Are these differences real, and what do they mean?