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Articles with the topic: psychiatric-symptoms

Through the eyes of a friend: changes in mood and behavior in early HD

Through the eyes of a friend: changes in mood and behavior in early HD

Leora Fox on December 02, 2015

The family and friends of individuals with HD often tell doctors that they began to notice changes in behavior long before a diagnosis was made. To better understand these early signs, researchers analyzed a psychological questionnaire filled out yearly for a decade by thousands of HD mutation carriers and their companions. The companions were more likely to perceive worsening symptoms over time.

Can sad mice help treat Huntington's disease?

Can sad mice help treat Huntington's disease?

Dr Jeff Carroll on July 17, 2013

Many Huntington's disease patients suffer from depression. New mouse work from Asa Petersen's group in Lund, Sweden, suggests that part of the brain called the "hypothalamus" might play a role in this symptom of HD.

TRACK-HD reveals changes in HD mutation carriers, empowering future trials

TRACK-HD reveals changes in HD mutation carriers, empowering future trials

Prof Anne Rosser on December 05, 2011

The results of a two-year study of HD mutation carriers, called TRACK-HD, have just been released. These results prove that a number of changes, including thinking ability and brain changes, occur early in people carrying the HD mutation. Most importantly, these changes are suitable for use as endpoints in future clinical trials for drugs to prevent or delay the onset of HD.

TRACK-HD reveals significant changes in pre-symptomatic HD mutation carriers and patients

TRACK-HD reveals significant changes in pre-symptomatic HD mutation carriers and patients

Dr Jeff Carroll on November 01, 2010

TRACK-HD, an observational trial of people carrying the HD mutation has released data describing changes over the first year of the study. These data show that a number of changes can be robustly observed in a single year of observing HD patients, which could be used to help plan drug trials. Brain imaging, in particular, was able to clearly see changes caused by the HD mutation.