Huntington’s disease research news. In plain language. Written by scientists. For the global HD community.

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Articles with the topic: PBT2

Prana announces results of Reach2HD trial of PBT2 for Huntington's disease

Prana announces results of Reach2HD trial of PBT2 for Huntington's disease

Dr Jeff Carroll on February 20, 2014

The results are in from the Reach2HD study, which was designed to test the experimental drug PBT2 for early and mid-stage Huntington's disease. The drug seems safe and well-tolerated at the doses that were tested, but we have major concerns about the way the results have been reported.

Joint HDBuzz Prizewinner: Pennies for your neurons — copper’s bad influence on Huntington’s disease

Joint HDBuzz Prizewinner: Pennies for your neurons — copper’s bad influence on Huntington’s disease

Terry Jo Bichell on January 30, 2014

Copper, the metal, may play a role in worsening the symptoms of Huntington’s disease. Bing Zhou and his team looked for connections between HD and the amount of copper in neurons. They report that reducing copper in neurons or keeping it from binding to the HD protein improves symptoms.

Prana Biotech publishes Huntington's disease animal model data for PBT2

Prana Biotech publishes Huntington's disease animal model data for PBT2

Dr Jeff Carroll on January 14, 2013

The Huntington Study Group and Prana Biotechnology are currently running a clinical trial, Reach2HD, to determine whether the drug PBT2 is effective in HD patients. Now, they've released the preclinical data behind the trial, showing the drug is effective in two animal models of HD.

EuroBuzz News: Day 2

EuroBuzz News: Day 2

Dr Ed Wild on September 15, 2012

Our second daily report from the European Huntington’s Disease Network 2012 Meeting in Stockholm. Video of both EuroBuzz evening sessions will be available to watch on HDBuzz.net next week.

Prana Biotech's new trial of PBT2 in Huntington's disease: the lowdown

Prana Biotech's new trial of PBT2 in Huntington's disease: the lowdown

Dr Ed Wild on October 03, 2011

Prana Biotech has announced a phase 2 clinical trial in Huntington's disease patients in Australia and the USA. Here's what we know so far about the trial, the company, the drug and the friendship between copper and the mutant huntingtin protein.