Huntington’s disease research news. In plain language. Written by scientists. For the global HD community.

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Articles with the topic: gene-therapy

Important advances in next generation genome editing tools for Huntington's Disease

Important advances in next generation genome editing tools for Huntington's Disease

Mr. Shawn Minnig on October 31, 2016

Recent days have seen a slew of news emerging regarding the use of something called genome editing as a potential therapy for genetic diseases like Huntington's Disease. These approaches, which include exotic sounding tools like zinc finger nucleases and CRISPR/Cas9, differ from more traditional ways reducing the impact of the HD mutation on cells. What's new in this exciting area of research?

Could a new "jaw-dropping" breakthrough help treat Huntington's Disease?

Could a new "jaw-dropping" breakthrough help treat Huntington's Disease?

Dr Jeff Carroll on February 25, 2016

Recent days have seen a torrent of news stories about a new technology, called CRISPR, which has been described as having potential application in Huntington's disease. Is this new technique as cool as it sounds? Possibly — but, as always, the truth is more complicated than the headlines suggest.

Giving Huntington's disease the finger? Two teams report success for zinc-finger drugs in cells and mice

Giving Huntington's disease the finger? Two teams report success for zinc-finger drugs in cells and mice

Dr Ed Wild on November 01, 2012

Designing drugs that tell our cells to make less of the harmful mutant huntingtin protein is one of the most promising approaches to treating Huntington's disease. Most huntingtin-lowering attempts so far have tried to 'shoot the messenger' rather than attacking the source of the message - the DNA itself. Now, two independent reports of success in HD mice have given a boost to 'zinc finger' drugs - which interact directly with the HD gene itself. It's early days for this new technology: what do we know, and what challenges are ahead?

Gene therapy meets stem cells in liver disease success

Gene therapy meets stem cells in liver disease success

Dr Michael Orth on December 26, 2011

Gene therapy could correct spelling mistakes in our DNA, while stem cells promise transplant operations that don't need powerful immune suppressing drugs. Scientists have now combined the two techniques in a genetic liver disease. Several challenges remain before this could work in Huntington's disease though.

Ten golden rules for reading a scientific news story

Ten golden rules for reading a scientific news story

Dr Ed Wild on September 05, 2011

Real progress is being made on the road to Huntington's disease treatments, but sometimes it feels like scientists promise more than they can deliver. So, HDBuzz has come up with ten 'golden rules' to help you decide whether a news story or press release offers genuine promise for HD, or whether its claims should be taken with a pinch of salt.

Cut-and-paste DNA: fixing mutations with 'genome editing'

Cut-and-paste DNA: fixing mutations with 'genome editing'

Dr Jeff Carroll on July 18, 2011

What if we could edit the DNA of patients to remove the Huntington's disease mutation altogether? Sounds like science fiction, but new research in an animal model of hemophilia suggests that it can work - and now HD researchers are on the case.