Huntington’s disease research news. In plain language. Written by scientists. For the global HD community.

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Articles with the topic: motor-function

Deutetrabenazine for Huntington's disease: a positive trial but the FDA says no? Not exactly...

Deutetrabenazine for Huntington's disease: a positive trial but the FDA says no? Not exactly...

Dr Peter McColgan on August 17, 2016

A scientific paper declares positive results for a trial of deutetrabenazine in Huntington's disease, but the headlines report the FDA has rejected the drug. Confusing stuff! The reality is positive overall for this new way of treating uncontrollable movements in HD, but patience will be needed to see where it all ends up.

Positive results announced for re-worked tetrabenazine drug in Huntington's disease

Positive results announced for re-worked tetrabenazine drug in Huntington's disease

Dr Jeff Carroll on December 22, 2014

Auspex Pharmaceuticals just announced the results of two clinical trials known as 'First-HD' and 'Arc-HD'. These trials were designed to test a modified version of the approved Huntington's disease drug tetrabenazine, which reduces unwanted movements. The results reveal that Auspex's drug has some advantages compared to tetrabenazine for treating excessive movements in HD.

More evidence points to Huntington's disease exercise benefit

More evidence points to Huntington's disease exercise benefit

Dr Tamara Maiuri on December 09, 2013

A news article reports that a "breakthrough" program of physical, mental, and social stimulation could "halt Huntington's progression". Sounds pretty exciting — but does the science back up the hype?

Buzzilia Video: Day 2

Buzzilia Video: Day 2

Dr Ed Wild on October 19, 2013

Here's Buzzilia, video 2: highlights and interviews from the World Congress on Huntington's disease 2013 in Rio de Janeiro. Jeff and Ed discuss biomarkers and talk to Dr Ralf Reilmann about quantitative motor assessment, and Dr Julie Stout about cognitive problems.

Could muscle problems help explain movements in Huntington’s Disease patients?

Could muscle problems help explain movements in Huntington’s Disease patients?

Dr Kurt Jensen on September 06, 2013

A proper balance of electrically charged particles is required for muscle cells to respond appropriately to stimuli. However, a recent report by a group of scientists from California State Polytechnic University concludes that disruption of this balance occurs in Huntington's disease – causing HD mouse muscle fibers to contract more easily than they should.

No surprises in published results from HART study of Huntexil for Huntington's disease

No surprises in published results from HART study of Huntexil for Huntington's disease

Dr Ed Wild on March 12, 2013

A new paper in the journal Movement Disorders reports the findings of the HART study of pridopidine, also known as Huntexil - a new drug aimed at improving movements in people with Huntington's disease. Unfortunately this publication doesn't change much - a new, larger trial is still needed before we will know whether Huntexil works.

TRACK-HD reveals changes in HD mutation carriers, empowering future trials

TRACK-HD reveals changes in HD mutation carriers, empowering future trials

Prof Anne Rosser on December 05, 2011

The results of a two-year study of HD mutation carriers, called TRACK-HD, have just been released. These results prove that a number of changes, including thinking ability and brain changes, occur early in people carrying the HD mutation. Most importantly, these changes are suitable for use as endpoints in future clinical trials for drugs to prevent or delay the onset of HD.

Successful gene therapy trial in Parkinson’s Disease gives hope for HD

Successful gene therapy trial in Parkinson’s Disease gives hope for HD

Dr Jeff Carroll on March 31, 2011

Scientists have successfully used viruses to deliver genes to the brains of Parkinson’s Disease patients. The gene carried by the viruses improved the movement symptoms of patients receiving injections. This proves that gene therapy in the brain can work, providing hope for similar therapies in HD.

Huntexil for symptoms of Huntington's disease: where are we now?

Huntexil for symptoms of Huntington's disease: where are we now?

Dr Ed Wild on November 16, 2010

2010 was a big year for the small Danish pharmacology company NeuroSearch and its experimental drug, Huntexil, which aims to improve the movements and coordination of people with HD symptoms. What have NeuroSearch's two clinical trials - MermaiHD in Europe and HART in the USA - told us about the possible benefits of Huntexil - and what is likely to happen next?