Huntington’s disease research news. In plain language. Written by scientists. For the global HD community.

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Articles with the topic: autophagy

mTORC1 tips the scales in Huntington’s disease mice

mTORC1 tips the scales in Huntington’s disease mice

Joseph Ochaba on January 27, 2015

What happens when you have a broken part in a machine? You fix it! A new study shows that increasing the activity a critical piece of machinery called ‘mTORC1’ in a mouse model of Huntington’s disease leads to improved motor problems and brain abnormalities associated with the disease. These recently published findings may offer scientists a new target for therapeutic development in HD.

Exercise increases cellular recycling

Exercise increases cellular recycling

Dr Tony Hannan on May 11, 2012

We know that exercise slows down symptom progression in HD mice, but we don't know why. New research has shown that exercise boosts a cellular recycling process in mouse muscle. These findings could increase our understanding of HD and help develop drugs.

Focused drug screening leads to improved drugs to increase the rate of cellular recycling

Focused drug screening leads to improved drugs to increase the rate of cellular recycling

Dr Jeff Carroll on December 16, 2010

Build-up of unwanted chemicals in cells is one way the HD mutation causes damage to neurons. A cellular recycling process called autophagy is crucial to getting rid of these harmful chemicals. Now researchers have found a way of identifying safe drugs that can increase the rate of garbage disposal in HD.