Huntington’s disease research news. In plain language. Written by scientists. For the global HD community.

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Articles with the topic: observational

Planting trees together: The 2016 Huntington's Disease Society of America Convention

Planting trees together: The 2016 Huntington's Disease Society of America Convention

Dr Jeff Carroll on June 13, 2016

Nearly a thousand HD family members converged on Baltimore, Maryland for the 2016 Huntington’s Disease Society of America’s Annual Convention. We normally don’t write reports from patient and family conferences, but there was something special about the atmosphere of this year’s Convention that compelled us to pen a brief update.

Through the eyes of a friend: changes in mood and behavior in early HD

Through the eyes of a friend: changes in mood and behavior in early HD

Leora Fox on December 02, 2015

The family and friends of individuals with HD often tell doctors that they began to notice changes in behavior long before a diagnosis was made. To better understand these early signs, researchers analyzed a psychological questionnaire filled out yearly for a decade by thousands of HD mutation carriers and their companions. The companions were more likely to perceive worsening symptoms over time.

New tool to measure outcomes in Huntington’s Disease clinical trials

New tool to measure outcomes in Huntington’s Disease clinical trials

Megan Krench on September 03, 2015

When patients participate in clinical trials, there needs to be some type of readout to determine whether the new treatment worked. It’s important to know two key things: What to measure and how to measure it. In the case of HD, these obstacles have vexed scientists and doctors for years. The latest research comes up with a clever new approach to overcome both challenges in a new way. These results could offer a valuable tool to study new HD therapeutics entering clinical trials.

How long is too long? Rethinking the Huntington’s disease ‘gray area’

How long is too long? Rethinking the Huntington’s disease ‘gray area’

Dr Ed Wild on August 19, 2013

The Huntington's disease genetic test involves counting the number of CAGs at the start of the HD gene. Some results are in a 'gray area' - larger than normal but smaller than the range that causes HD. Now, by closely studying people with CAG counts in the intermediate range, the PHAROS study has found some subtle differences in mood and behavior. These results don't mean that intermediate CAG counts cause HD, but they do suggest they may have some effects on the brain, which need to be studied in more detail.

Landmark study puts Huntington's disease trials on TRACK

Landmark study puts Huntington's disease trials on TRACK

Dr Faye Begeti on May 09, 2013

If we find a therapy that we hope can slow down Huntington's disease, how can we prove that it works in patients? What tests should we do and how long should we follow people up after treatment in order to see any real benefits? A major new paper from Sarah Tabrizi and colleagues, reporting the final outcomes of the TRACK-HD study, provides information that will help us better design trials of new therapies in HD as well as understand how the disease progresses.

HD Therapeutics Conference 2013 Updates: Day 3

HD Therapeutics Conference 2013 Updates: Day 3

Dr Jeff Carroll on April 11, 2013

Our daily report from the annual Huntington's Disease Therapeutics Conference in Venice, Italy on the third and final day of the conference.

Illuminating findings in blood cells from Huntington's disease patients

Illuminating findings in blood cells from Huntington's disease patients

Dr Jeff Carroll on November 06, 2012

With gene silencing therapies heading towards the clinic, a new question has arisen - how will we know if they work? How can we tell if the amount of huntingtin protein is lowered in people? New work from London and Basel demonstrates that the huntingtin protein is detectable in blood samples, and that its levels change during the course of HD.

EuroBuzz Video: Day 1

EuroBuzz Video: Day 1

Dr Ed Wild on September 19, 2012

Jeff Carroll and Ed Wild present EuroBuzz episode 1 - bringing the European HD Network Meeting direct to you, in plain language. Watch online!

EuroBuzz News: Day 3

EuroBuzz News: Day 3

Dr Jeff Carroll on September 16, 2012

Our third and final daily report from the European Huntington’s Disease Network 2012 Meeting in Stockholm. Video of both EuroBuzz evening sessions will be available to watch on HDBuzz.net next week.